Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.36 |
| ▸ | BCL2 | P10415 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26648644 | 1.00 | BCL2L1 (0.40) | BCL2L1PTGS2PTGS1BCL2SLC6A3 | |
| SCHEMBL33529723 | 0.91 | BCL2L1 (0.40) | BCL2L1PTGS2PTGS1BCL2SLC6A3 | |
| SCHEMBL22325185 | 0.91 | BCL2L1 (0.40) | BCL2L1PTGS2PTGS1BCL2SLC6A3 | |
| SCHEMBL25215204 | 0.81 | BCL2L1 (0.51) | BCL2L1PTGS2PTGS1BCL2SLC6A3 | |
| SCHEMBL25254777 | 0.76 | PTGS2 (0.43) | BCL2L1PTGS2PTGS1BCL2SLC6A3 | |
| SCHEMBL1113744 | 0.76 | BCL2L1 (0.52) | BCL2L1PTGS2PTGS1BCL2SLC6A3 | |
| SCHEMBL30834678 | 0.74 | SLC6A3 (0.43) | SLC6A3SLC6A2LMNAMAPK1NPSR1 | |
| SCHEMBL1959392 | 0.74 | PTGS2 (0.45) | BCL2L1PTGS2PTGS1BCL2SLC6A3 | |
| SCHEMBL25244236 | 0.73 | PTGS2 (0.42) | BCL2L1PTGS2PTGS1SLC6A3SLC6A2 | |
| SCHEMBL5394022 | 0.72 | SMN1; SMN2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220425-A1 | BCL-XL/BCL-2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| EP-3920923-A2 | THERAPEUTIC AGENTS AND METHODS OF TREATMENT | University of Florida Research Foundation, Incorporated (US) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020163823-A2 | THERAPEUTIC AGENTS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2020-08-13 | — | — | WO | disclosed |