Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | PPP5C | P53041 | 1/20 | 0.31 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.30 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25394185 | 0.92 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAPOLBCHRM1GBA2 | |
| SCHEMBL25394536 | 0.91 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAPOLBCHRM2CHRM1 | |
| SCHEMBL29827074 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAPOLBCHRM2CHRM1 | |
| SCHEMBL26923244 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAPOLBCHRM1GBA2 | |
| SCHEMBL14145633 | 0.76 | CHRM1 (0.56) | LMNACHRM2CHRM1CHRM3 | |
| SCHEMBL26923262 | 0.74 | LMNA (0.38) | SMN1; SMN2LMNAPOLBCHRM1GBA2 | |
| SCHEMBL26923200 | 0.74 | LMNA (0.38) | SMN1; SMN2LMNAPOLBCHRM2CHRM1 | |
| SCHEMBL31692676 | 0.74 | LMNA (0.43) | SMN1; SMN2LMNAPOLBCHRM1GBA2 | |
| SCHEMBL8259202 | 0.74 | LMNA (0.43) | SMN1; SMN2LMNAPOLBCHRM2CHRM1 | |
| SCHEMBL29838433 | 0.73 | LMNA (0.47) | SMN1; SMN2LMNAPOLBGBA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3921311-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | Skyhawk Therapeutics, Inc. (US) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020163647-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. (US) | 2020-08-13 | — | — | WO | disclosed |