Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 4/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22325282 | 0.92 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNAPOLBALDH1A1ATM | |
| SCHEMBL25394536 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAPOLBALDH1A1ATM | |
| SCHEMBL26923244 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAPOLBALDH1A1ATM | |
| SCHEMBL26923262 | 0.81 | LMNA (0.38) | SMN1; SMN2LMNAPOLBALDH1A1ATM | |
| SCHEMBL31692676 | 0.81 | LMNA (0.43) | SMN1; SMN2LMNAPOLBALDH1A1ATM | |
| SCHEMBL26922978 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAPOLBALDH1A1ATM | |
| SCHEMBL26923200 | 0.78 | LMNA (0.38) | SMN1; SMN2LMNAPOLBALDH1A1ATM | |
| SCHEMBL8259202 | 0.77 | LMNA (0.43) | SMN1; SMN2LMNAPOLBALDH1A1ATM | |
| SCHEMBL12199159 | 0.77 | LMNA (0.45) | SMN1; SMN2LMNAPOLBALDH1A1ATM | |
| SCHEMBL30532513 | 0.76 | LMNA (0.42) | SMN1; SMN2LMNAPOLBALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023168298-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | DENALI THERAPEUTICS INC. (US) | 2023-09-07 | — | — | WO | disclosed |