Sugi Predict

Sugi Predict / Compounds / SCHEMBL22326116

SCHEMBL22326116

SCHEMBL22326116

FC(F)(F)Oc1ccc(C(c2ccc(OC(F)(F)F)cc2)C(F)(F)F)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ESR1 P03372 1/20 0.54
▸ ESR2 Q92731 1/20 0.54
▸ PDE2A O00408 1/20 0.49
▸ ALDH1A1 P00352 3/20 0.44
▸ MAPT P10636 3/20 0.42
▸ EPHX2 P34913 1/20 0.42
▸ GPR3 P46089 1/20 0.39
▸ TOP2A P11388 1/20 0.39
▸ TOP2B Q02880 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ SLC7A5 Q01650 2/20 0.38
▸ AKR1C2 P52895 1/20 0.38
▸ AKR1C1 Q04828 1/20 0.38
▸ L3MBTL1 Q9Y468 2/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ MEN1 O00255 2/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ SLC6A2 P23975 1/20 0.38
▸ SLC6A4 P31645 1/20 0.38
▸ SLC6A3 Q01959 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL254957 0.80 MAPT (0.56) PDE2AALDH1A1MAPTEPHX2GPR3
SCHEMBL3484598 0.79 PDE2A (0.50) PDE2AALDH1A1MAPTEPHX2GPR3
SCHEMBL21514785 0.78 PDE2A (0.46) PDE2AALDH1A1MAPTEPHX2GPR3
SCHEMBL8848833 0.78 PDE2A (0.46) PDE2AALDH1A1MAPTEPHX2GPR3
SCHEMBL16563163 0.78 PDE2A (0.46) PDE2AALDH1A1MAPTEPHX2GPR3
SCHEMBL10194680 0.78 PDE2A (0.54) PDE2AALDH1A1MAPTEPHX2L3MBTL1
SCHEMBL24017149 0.77 PDE2A (0.49) PDE2AALDH1A1MAPTEPHX2GPR3
SCHEMBL2056155 0.77 PDE2A (0.58) ESR1ESR2PDE2AALDH1A1MAPT
SCHEMBL646645 0.77 PDE2A (0.49) PDE2AALDH1A1MAPTEPHX2GPR3
SCHEMBL24017106 0.77 PDE2A (0.49) PDE2AALDH1A1MAPTEPHX2GPR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12435185-B2 Method for producing 1,1,1-trifluoro-2,2-bisarylethane, and 1,1,1-trifluoro-2,2-bisarylethane CENTRAL GLASS COMPANY, LIMITED (JP) 2025-10-07 — — US disclosed
US-20220106444-A1 Method for Producing 1,1,1-Trifluoro-2,2-Bisarylethane, and 1,1,1-Trifluoro-2,2-Bisarylethane CENTRAL GLASS COMPANY, LIMITED (JP) 2022-04-07 — — US disclosed
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 — — WO disclosed
WO-2020162408-A1 METHOD FOR PRODUCING 1,1,1-TRIFLUORO-2,2-BISARYLETHANE, AND 1,1,1-TRIFLUORO-2,2-BISARYLETHANE セントラル硝子株式会社 2020-08-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220106444-A1 Method for Producing 1,1,1-Trifluoro-2,2-Bisarylethane, and 1,1,1-Trifluoro-2,2-Bisarylethane NAF1, FXR1, AFF1 ESR1 4737/4885ESR2 3744/4885PDE2A 4039/4885
US-12435185-B2 Method for producing 1,1,1-trifluoro-2,2-bisarylethane, and 1,1,1-trifluoro-2,2-bisarylethane NAF1, FXR1, AFF1 ESR1 4737/4885ESR2 3744/4885PDE2A 4039/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.