Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22326247 | 0.85 | KDM4E (0.43) | PLA2G4BLMNAKDM4ESLC7A5ALDH1A1 | |
| SCHEMBL3334714 | 0.84 | ALDH1A1 (0.51) | PLA2G4BKDM4ESLC7A5ALDH1A1GAA | |
| SCHEMBL25081996 | 0.82 | PLA2G4B (0.58) | PLA2G4BKDM4ECYP4F2CYP4A11NR1H3 | |
| SCHEMBL25081995 | 0.82 | PLA2G4B (0.58) | PLA2G4BKDM4ECYP4F2CYP4A11NR1H3 | |
| SCHEMBL25081997 | 0.82 | PLA2G4B (0.58) | PLA2G4BKDM4ECYP4F2CYP4A11NR1H3 | |
| SCHEMBL30278808 | 0.82 | PLA2G4B (0.58) | PLA2G4BKDM4ECYP4F2CYP4A11NR1H3 | |
| SCHEMBL28588436 | 0.81 | KMT2A (0.55) | PLA2G4BLMNAKDM4ESLC7A5ALDH1A1 | |
| SCHEMBL22326323 | 0.81 | PLA2G4B (0.55) | PLA2G4BKDM4ESLC7A5PPARAPPARG | |
| SCHEMBL334386 | 0.80 | SLC7A5 (0.48) | PLA2G4BKDM4ESLC7A5ALDH1A1GAA | |
| SCHEMBL2767522 | 0.80 | SLC7A5 (0.48) | PLA2G4BKDM4ESLC7A5ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020162725-A1 | TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT | 한국화학연구원 | 2020-08-13 | — | — | WO | disclosed |