Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.34 |
| ▸ | JAK1 | P23458 | 11/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23228228 | 0.83 | JAK2 (0.37) | JAK2JAK1CTSS | |
| SCHEMBL24222050 | 0.77 | JAK2 (0.34) | JAK2JAK1CTSS | |
| SCHEMBL8259942 | 0.74 | RAB9A (0.42) | JAK2JAK1CTSS | |
| SCHEMBL26777912 | 0.74 | JAK2 (0.36) | JAK2JAK1CTSS | |
| SCHEMBL23619294 | 0.73 | LMNA (0.32) | — | |
| SCHEMBL22381533 | 0.72 | PNP (0.42) | — | |
| SCHEMBL21127785 | 0.71 | HPRT1 (0.48) | — | |
| SCHEMBL22399677 | 0.71 | JAK2 (0.33) | JAK2JAK1CTSS | |
| SCHEMBL13181197 | 0.70 | SMN1; SMN2 (0.38) | JAK2JAK1CTSS | |
| SCHEMBL15723760 | 0.70 | MEN1 (0.41) | JAK2JAK1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738074-B2 | Cyclic di-nucleotide compounds as STING agonists | MERCK SHARP & DOHME CORP. (US) | 2020-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10738074-B2 | Cyclic di-nucleotide compounds as STING agonists | STING1, CGAS, IFNAR1 | JAK2 1763/4885JAK1 640/4885CTSS 3880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.