Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.33 |
| ▸ | PDE4A | P27815 | 4/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24499701 | 0.80 | ALDH1A1 (0.37) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL18520816 | 0.77 | ALDH1A1 (0.42) | ALDH1A1ADORA2AMAPTHPGDBLM | |
| SCHEMBL22547338 | 0.74 | ALDH1A1 (0.39) | ALDH1A1ADORA2AMAPTHPGDBLM | |
| SCHEMBL22349704 | 0.73 | ALDH1A1 (0.39) | ALDH1A1MAPTHPGDHTT | |
| SCHEMBL22349659 | 0.72 | ALDH1A1 (0.33) | ALDH1A1ADORA2APDE4APDE4BPDE4C | |
| SCHEMBL22399904 | 0.71 | ALDH1A1 (0.37) | ALDH1A1CYP1A2MAPTMEN1KMT2A | |
| SCHEMBL22797271 | 0.70 | PDE4A (0.33) | ALDH1A1ADORA2APDE4APDE4BPDE4C | |
| SCHEMBL22399282 | 0.69 | ALDH1A1 (0.36) | ALDH1A1CYP1A2 | |
| SCHEMBL22797115 | 0.68 | KDM6B (0.34) | ALDH1A1ADORA2APDE4APDE4BPDE4C | |
| SCHEMBL13201566 | 0.67 | ALDH1A1 (0.39) | ALDH1A1HPGDHSD17B10NR1H2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10738074-B2 | Cyclic di-nucleotide compounds as STING agonists | MERCK SHARP & DOHME CORP. (US) | 2020-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10738074-B2 | Cyclic di-nucleotide compounds as STING agonists | STING1, CGAS, IFNAR1 | ALDH1A1 4323/4885ADORA2A 72/4885PDE4A 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.