SCHEMBL2233154

SCHEMBL2233154

Nc1ccc(C(=O)N(Cc2ccccc2)C2CCNCC2)cc1

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
AGER Q15109 3/20 0.58
MTNR1A P48039 1/20 0.58
CHRM2 P08172 1/20 0.55
CHRM3 P20309 1/20 0.55
HSD17B10 Q99714 1/20 0.50
DCUN1D1 Q96GG9 1/20 0.48
SLC6A4 P31645 5/20 0.48
KCNH2 Q12809 2/20 0.48
SLC6A2 P23975 4/20 0.47
SLC6A3 Q01959 2/20 0.47
NSD2 O96028 1/20 0.47
ALDH1A1 P00352 1/20 0.45
LMNA P02545 1/20 0.45
MBTPS1 Q14703 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2233149 0.87 AGER (0.58) AGERMTNR1ACHRM2CHRM3HSD17B10
SCHEMBL3811903 0.83 DCUN1D1 (0.58) AGERMTNR1ACHRM2CHRM3DCUN1D1
Hydrochloric Acid SCHEMBL21410210 0.82 DCUN1D1 (0.57) AGERMTNR1ACHRM2CHRM3DCUN1D1
SCHEMBL6622412 0.81 DCUN1D1 (0.54) AGERMTNR1ACHRM2CHRM3DCUN1D1
SCHEMBL4131042 0.79 DCUN1D1 (0.53) DCUN1D1SLC6A4KCNH2SLC6A2SLC6A3
SCHEMBL7372912 0.79 AGER (0.49) AGERMTNR1ACHRM2CHRM3HSD17B10
SCHEMBL619150 0.78 SLC6A2 (0.71) AGERMTNR1ACHRM2CHRM3DCUN1D1
SCHEMBL4198203 0.77 OPRM1 (0.62) DCUN1D1SLC6A4KCNH2SLC6A2SLC6A3
Hydrochloric Acid SCHEMBL22797899 0.77 SLC6A2 (0.70) AGERMTNR1ACHRM2CHRM3DCUN1D1
SCHEMBL2733320 0.77 SLC6A2 (0.53) CHRM3SLC6A4KCNH2SLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2528920-A2 BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE Hanmi Pharm. Co., Ltd. (KR) 2012-12-05 EP claimed
WO-2011093672-A2 BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE HANMI PHARM. CO., LTD. (KR) 2011-08-04 WO claimed