Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17319467 | 1.00 | TSHR (0.42) | TSHRTP53CA12CA1CA2 | |
| SCHEMBL2531832 | 0.85 | TP53 (0.39) | TSHRTP53CA12CA1CA2 | |
| SCHEMBL2236544 | 0.83 | TP53 (0.47) | TP53CA1CA2 | |
| SCHEMBL11350925 | 0.81 | TSHR (0.43) | TSHRTP53CA12CA1CA2 | |
| SCHEMBL6729264 | 0.79 | TSHR (0.42) | TSHRTP53CA12CA1CA2 | |
| SCHEMBL1705201 | 0.78 | — | — | |
| SCHEMBL22267540 | 0.78 | TSHR (0.46) | TSHR | |
| SCHEMBL23805180 | 0.77 | TSHR (0.40) | TSHRTP53CA12CA1CA2 | |
| SCHEMBL5075666 | 0.77 | TSHR (0.40) | TSHRTP53CA12CA1CA2 | |
| SCHEMBL5076462 | 0.77 | TSHR (0.40) | TSHRTP53CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466324-B2 | Sulfone compound | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2013-06-18 | — | — | US | disclosed |
| US-20110257438-A1 | SULFONE COMPOUND | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2011-10-20 | — | — | US | disclosed |
| EP-2360143-A1 | SULFONE COMPOUND | Sumitomo Seika Chemicals CO. LTD. (JP) | 2011-08-24 | — | — | EP | disclosed |
| US-20100130468-A1 | INDOLE CARBOXAMIDES AS IKK2 INHIBITORS | GLAXOSMITHKLINE LLC | 2010-05-27 | — | — | US | disclosed |
| US-RE39679-E1 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-06-05 | — | — | US | disclosed |
| US-6713471-B1 | SUCH AS TERT-BUTYL-1-METHYL-6,7,9,12-TETRAHYDRO-5H-PYRIDO-(4,3-B)(1,4) THIAZEPINO(2,3,4-HI)INDOLE-11(10H)-CARBOXYLATE; SEROTONIN AGONISTS AND ANTAGONISTS; CENTRAL NERVOUS SYSTEM DISORDERS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-30 | — | — | US | disclosed |
| EP-1192165-A2 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES | Bristol-Myers Squibb Pharma Company (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077010-A2 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130468-A1 | INDOLE CARBOXAMIDES AS IKK2 INHIBITORS | IDO2, IDO1, NFKBIA | TSHR 2451/4885TP53 2748/4885CA12 2825/4885 |
| US-20110257438-A1 | SULFONE COMPOUND | SULT1E1, SULT1A1, STS | TSHR 3222/4885TP53 4133/4885CA12 197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.