Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.87 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.73 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.73 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.73 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.73 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.73 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.73 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.73 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.73 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.73 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.73 |
| ▸ | FBP1 | P09467 | 2/20 | 0.71 |
| ▸ | AURKA | O14965 | 1/20 | 0.70 |
| ▸ | INSR | P06213 | 1/20 | 0.70 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.70 |
| ▸ | FLT4 | P35916 | 1/20 | 0.70 |
| ▸ | KDR | P35968 | 1/20 | 0.70 |
| ▸ | CLK1 | P49759 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22338174 | 0.95 | EGFR (0.80) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL15217656 | 0.94 | EGFR (0.90) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL1730545 | 0.93 | EGFR (1.00) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL24535320 | 0.89 | EGFR (0.72) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL25083284 | 0.89 | EGFR (0.71) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL18978997 | 0.87 | EGFR (0.89) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL8211574 | 0.87 | HDAC3 (0.89) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL10118455 | 0.87 | HDAC3 (0.83) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL6994526 | 0.87 | EGFR (0.69) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL4343029 | 0.87 | EGFR (0.87) | EGFRERBB2HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020163598-A1 | IMMUNOPHILIN-DEPENDENT INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-08-13 | — | — | WO | disclosed |