SCHEMBL2233813

SCHEMBL2233813

CC(=O)CC(CO)CC(=O)O

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.42
ALDH1A1 P00352 1/20 0.42
CACNA2D1 P54289 2/20 0.40
CACNB3 P54284 1/20 0.40
CACNA1C Q13936 1/20 0.40
PGR P06401 1/20 0.40
ADRA1A P35348 1/20 0.40
HTR2B P41595 1/20 0.40
CACNA2D2 Q9NY47 1/20 0.40
SLC22A6 Q4U2R8 1/20 0.38
LMNA P02545 3/20 0.36
SLC15A2 Q16348 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.35
ALOX15 P16050 1/20 0.33
MAPT P10636 1/20 0.33
GABRR1 P24046 2/20 0.32
MME P08473 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14513819 0.89 ALDH1A1 (0.50) TDP1ALDH1A1LMNASLC15A2
SCHEMBL28363512 0.87 TDP1 (0.48) TDP1ALDH1A1CACNA2D1CACNB3CACNA1C
SCHEMBL619735 0.87 SLC22A6 (0.47) TDP1CACNA2D1CACNB3CACNA1CPGR
Acetone SCHEMBL28340425 0.84 CACNA2D1 (0.43) TDP1ALDH1A1CACNA2D1CACNB3CACNA1C
SCHEMBL9734057 0.84
SCHEMBL45197 0.81
SCHEMBL8055157 0.80 TDP1 (0.42) TDP1ALDH1A1CACNA2D1CACNB3CACNA1C
SCHEMBL11519298 0.79 LMNA (0.42) TDP1ALDH1A1CACNA2D1CACNB3CACNA1C
Alcohol SCHEMBL28947608 0.79 CACNA2D1 (0.43) TDP1ALDH1A1CACNA2D1CACNB3CACNA1C
SCHEMBL5165804 0.78 SLC22A6 (0.45) TDP1CACNA2D1CACNB3CACNA1CPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110873766-A Mass spectrometry method for screening protein with structure and interaction change caused by drug 中国科学院大连化学物理研究所 2020-03-10 CN disclosed
EP-2360152-A1 TWO TYPES OF CRYSTALLINE OF PINOCEMBRIN: A AND B, THEIR PREPARATION AND THEIR USE FOR MANUFACTURE OF PHARMACEUTICAL COMPOSITIONS CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) 2011-08-24 EP disclosed
EP-0708837-B1 FLUORESCENT POLYMER LABELED CONJUGATES AND INTERMEDIATES ABBOTT LAB (US) 2006-03-08 EP disclosed
EP-0708837-A4 FLUORESCENT POLYMER LABELED CONJUGATES AND INTERMEDIATES ABBOTT LAB (US) 2002-11-20 EP disclosed
WO-1999031511-A1 IMMUNOASSAY FOR HORMONE DETECTION STICHTING INSTITUUT VOOR DIERHOUDERIJ EN DIERGEZONDHEID (NL) 1999-06-24 WO disclosed
US-5661040-A RECEPTOR BINDING ASSAYS ABBOTT LABORATORIES (US) 1997-08-26 US disclosed
US-5639904-A CARDIOVASCULAR DISORDERS PRODESFARMA, S.A. (ES) 1997-06-17 US disclosed
EP-0708837-A1 FLUORESCENT POLYMER LABELED CONJUGATES AND INTERMEDIATES ABBOTT LABORATORIES (US) 1996-05-01 EP disclosed
US-5502237-A VASODILATORS, ADRENERGIC BLOCKING AGENTS PRODESFARMA, S. A. (ES) 1996-03-26 US disclosed
WO-1995002700-A1 FLUORESCENT POLYMER LABELED CONJUGATES AND INTERMEDIATES ABBOTT LABORATORIES (US) 1995-01-26 WO disclosed
US-4255564-A ANTIBIOTICS, PROTECTED ALDEHYDE GROUP, INTERMEDIATES ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) 1981-03-10 US disclosed