Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prednisolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 10/20 | 0.90 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.90 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.90 |
| ▸ | PGR | P06401 | 5/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.90 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.90 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.90 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.90 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.90 |
| ▸ | TNF | P01375 | 1/20 | 0.90 |
| ▸ | IL6 | P05231 | 1/20 | 0.90 |
| ▸ | AR | P10275 | 1/20 | 0.90 |
| ▸ | GLUL | P15104 | 1/20 | 0.90 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.90 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.90 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednisolone SCHEMBL23564 | 1.00 | NR3C1 (0.90) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL4751186 | 0.97 | NR3C1 (0.85) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL1930093 | 0.97 | NR3C1 (0.88) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL7514 | 0.95 | NR3C1 (0.93) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL16094487 | 0.95 | NR3C1 (0.93) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL5504548 | 0.95 | NR3C1 (0.93) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL23863778 | 0.95 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL13044469 | 0.95 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL2737385 | 0.95 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL765329 | 0.95 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117337297-A | Use of SOS1 inhibitors and MTOR inhibitors for the treatment of cancer | 锐新医药公司 | 2024-01-02 | — | — | CN | disclosed |
| US-20230041980-A1 | METHOD OF PROTECTING A RESPIRATORY TRACT OR A LUNG FROM DAMAGE, METHOD OF PROTECTING A LUNG FROM PRESSURE DAMAGE INDUCED BY A VENTILATOR, METHOD OF SUPPRESSING SPREAD OF INFECTION WITH VIRUSES OR BACTERIA THAT CAUSE PNEUMONIA IN PULMONARY BRONCHIAL EPITHELIAL CELLS OR ALVEOLAR EPITHELIAL CELLS, AND NASAL SPRAY | NEXT21 KABUSHIKI KAISHA (JP) | 2023-02-09 | — | — | US | disclosed |
| EP-4125927-A1 | MEDICINE CONTAINING TREHALOSE OR TREHALOSE DERIVATIVE AND NASAL SPRAY | Next21 Kabushiki Kaisha (JP) | 2023-02-08 | — | — | EP | disclosed |
| WO-2021210648-A1 | MEDICINE CONTAINING TREHALOSE OR TREHALOSE DERIVATIVE AND NASAL SPRAY | NEXT21 KABUSHIKI KAISHA (JP) | 2021-10-21 | — | — | WO | disclosed |
| WO-2021025140-A1 | DUAL-SPECIFIC PROTEIN | 小野薬品工業株式会社 | 2021-02-11 | — | — | WO | disclosed |
| WO-2021020416-A1 | BISPECIFIC ANTIBODY | 小野薬品工業株式会社 | 2021-02-04 | — | — | WO | disclosed |
| WO-2019172419-A1 | METHOD FOR DETECTING INDICATOR OF IMMUNE-RELATED DISEASE | 株式会社マンダム | 2019-09-12 | — | — | WO | disclosed |
| WO-2019163838-A1 | MARKER FOR MULTIPLE SCLEROSIS | 国立研究開発法人理化学研究所 | 2019-08-29 | — | — | WO | disclosed |
| WO-2019156199-A1 | BISPECIFIC ANTIBODY | 小野薬品工業株式会社 | 2019-08-15 | — | — | WO | disclosed |
| EP-2353592-A1 | Therapeutic causing contraction of mucosal tissue and method of treating diseases relating to mucosal tissues | Japan Science and Technology Agency (JP) | 2011-08-10 | — | — | EP | disclosed |
| US-20050187303-A1 | Therapeutic causing contraction of mucosal tissue, method of treating diseases relating to mucosal tissues, injector and therapeutic set | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2005-08-25 | — | — | US | disclosed |
| EP-1557163-A1 | THERAPEUTIC CAUSING CONTRACTION OF MUCOSAL TISSUE, METHOD OF TREATING DISEASES RELATING TO MUCOSAL TISSUES, INJECTOR AND THERAPEUTIC SET | Japan Science and Technology Agency (JP) | 2005-07-27 | — | — | EP | disclosed |
| EP-1197209-A1 | PERCUTANEOUSLY ABSORBABLE PREPARATIONS | HISAMITSU PHARMACEUTICAL CO. INC. (JP) | 2002-04-17 | — | — | EP | disclosed |
| EP-1190706-A1 | LIPOSOMES | TERUMO KABUSHIKI KAISHA (JP) | 2002-03-27 | — | — | EP | disclosed |
| EP-0953357-A1 | NEPHROTROPIC DRUGS | Drug Delivery System Institute, Ltd. (JP) | 1999-11-03 | — | — | EP | disclosed |
| EP-0308572-B1 | An iontophoresis device | HISAMITSU PHARMACEUTICAL CO (JP) | 1995-11-08 | — | — | EP | disclosed |
| EP-0138347-B1 | AN IONTOPHORESIS DEVICE | KABUSHIKI KAISYA ADVANCE (JP) | 1989-08-02 | — | — | EP | disclosed |
| EP-0308572-A2 | An iontophoresis device | Hisamitsu Pharmaceutical Co., Inc. (JP) | 1989-03-29 | — | — | EP | disclosed |
| US-4764164-A | Iontophoresis device | KABUSHIKI KAISYA ADVANCE KAIHATSU KENKYUJO (JP) | 1988-08-16 | — | — | US | disclosed |
| EP-0138347-A1 | An iontophoresis device | KABUSHIKI KAISYA ADVANCE (JP) | 1985-04-24 | — | — | EP | disclosed |