Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prednisolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 10/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 9/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 1.00 |
| ▸ | PGR | P06401 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | SERPINA6 | P08185 | 2/20 | 1.00 |
| ▸ | NR3C2 | P08235 | 2/20 | 1.00 |
| ▸ | TNF | P01375 | 1/20 | 1.00 |
| ▸ | IL6 | P05231 | 1/20 | 1.00 |
| ▸ | AR | P10275 | 1/20 | 1.00 |
| ▸ | GLUL | P15104 | 1/20 | 1.00 |
| ▸ | ADAM17 | P78536 | 1/20 | 1.00 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednisolone SCHEMBL12396679 | 1.00 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL14420691 | 1.00 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL2737385 | 1.00 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL6566835 | 1.00 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL4449434 | 1.00 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL11413677 | 1.00 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL23863778 | 1.00 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL13044469 | 1.00 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL2597917 | 1.00 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 | |
| Prednisolone SCHEMBL29264693 | 1.00 | NR3C1 (1.00) | NR3C1HIF1AHSD17B10PGRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE46190-E1 | High-molecular weight conjugate of steroids | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2016-11-01 | — | — | US | disclosed |
| US-RE46190-E1 | High-molecular weight conjugate of steroids | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2016-11-01 | — | — | US | disclosed |
| EP-2431403-B1 | POLYMER CONJUGATE OF BIOACTIVE SUBSTANCE HAVING HYDROXY GROUP | NIPPON KAYAKU KK (JP) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015063408-A2 | METHOD FOR PREPARING STEROIDAL DERIVATIVES | SANOFI (FR) | 2015-05-07 | — | — | WO | disclosed |
| US-8808749-B2 | Polymer conjugate of bioactive substance having hydroxy group | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2014-08-19 | — | — | US | disclosed |
| US-8808749-B2 | Polymer conjugate of bioactive substance having hydroxy group | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2014-08-19 | — | — | US | disclosed |
| US-8703878-B2 | High-molecular weight conjugate of steroids | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2014-04-22 | — | — | US | disclosed |
| US-8703878-B2 | High-molecular weight conjugate of steroids | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2014-04-22 | — | — | US | disclosed |
| US-20120116051-A1 | Polymer Conjugate Of Bioactive Substance Having Hydroxy Group | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2012-05-10 | — | — | US | disclosed |
| US-20120116051-A1 | Polymer Conjugate Of Bioactive Substance Having Hydroxy Group | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2012-05-10 | — | — | US | disclosed |
| EP-2431403-A1 | POLYMER CONJUGATE OF BIOACTIVE SUBSTANCE HAVING HYDROXY GROUP | Nippon Kayaku Kabushiki Kaisha (JP) | 2012-03-21 | — | — | EP | disclosed |
| US-20100292414-A1 | High-Molecular Weight Conjugate Of Steroids | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2010-11-18 | — | — | US | disclosed |
| US-20100292414-A1 | High-Molecular Weight Conjugate Of Steroids | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292414-A1 | High-Molecular Weight Conjugate Of Steroids | CYP17A1, CYP21A2, HSD17B12 | NR3C1 74/4885HIF1A 2922/4885HSD17B10 16/4885 |
| US-20120116051-A1 | Polymer Conjugate Of Bioactive Substance Having Hydroxy Group | CTSL, CPA3, ADCY10 | NR3C1 1956/4885HIF1A 887/4885HSD17B10 294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.