Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20642383 | 0.86 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL19508069 | 0.79 | P2RX3 (0.35) | NOS3NOS1NOS2P2RX3P2RX2 | |
| SCHEMBL12190658 | 0.79 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL7117731 | 0.78 | NOS3 (0.48) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL19699399 | 0.78 | P2RX3 (0.35) | NOS3NOS1NOS2P2RX3P2RX2 | |
| SCHEMBL22416468 | 0.76 | NOS3 (0.40) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL10496086 | 0.76 | NOS3 (0.47) | SLC6A2SLC6A4SLC6A3NOS3NOS1 | |
| SCHEMBL12848758 | 0.75 | UHRF1 (0.41) | SLC6A2SLC6A4SLC6A3UHRF1CYP1A2 | |
| SCHEMBL19699682 | 0.75 | P2RX3 (0.42) | P2RX3P2RX2 | |
| SCHEMBL18929225 | 0.75 | NOS3 (0.39) | SLC6A2SLC6A4SLC6A3NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020163323-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. (US) | 2020-08-13 | — | — | WO | disclosed |