Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.72 |
| ▸ | JAK2 | O60674 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9152183 | 0.91 | GAA (0.72) | GAAJAK2LMNAMAPTDRD2 | |
| Methane SCHEMBL7356487 | 0.89 | GAA (0.69) | GAAJAK2LMNAMAPTDRD2 | |
| SCHEMBL9150153 | 0.88 | GAA (0.67) | GAAJAK2LMNAMAPTDRD2 | |
| SCHEMBL2637278 | 0.86 | GAA (0.95) | GAAJAK2LMNAMAPTDRD2 | |
| Alcohol SCHEMBL1545296 | 0.86 | GAA (0.64) | GAAJAK2LMNAMAPTDRD2 | |
| Methyl Alcohol SCHEMBL1545298 | 0.86 | GAA (0.64) | GAAJAK2LMNAMAPTDRD2 | |
| SCHEMBL5621969 | 0.84 | GAA (0.82) | GAAJAK2LMNAMAPTDRD2 | |
| SCHEMBL9045649 | 0.84 | GAA (0.82) | GAAJAK2LMNAMAPTDRD2 | |
| SCHEMBL6848695 | 0.84 | KDM4E (0.54) | GAAJAK2LMNAMAPTTP53 | |
| SCHEMBL24011910 | 0.82 | GAA (0.78) | GAAJAK2LMNAMAPTDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017031209-A1 | TUBULYSIN ANALOGS AND METHODS | ENDOCYTE, INC. (US) | 2017-02-23 | — | — | WO | disclosed |
| US-8829208-B2 | Process for the preparation of darunavir and darunavir intermediates | MAPI PHARMA LTD. (IL) | 2014-09-09 | — | — | US | disclosed |
| CN-1989122-B | Novel cyclopenta [ b ] benzofuran derivatives and uses thereof | INTERMED DISCOVERY GMBH | 2013-07-24 | — | — | CN | disclosed |
| EP-2528923-A1 | PROCESS FOR THE PREPARATION OF DARUNAVIR AND DARUNAVIR INTERMEDIATES | Mapi Pharma Limited (IL) | 2012-12-05 | — | — | EP | disclosed |
| US-20120296101-A1 | PROCESS FOR THE PREPARATION OF DARUNAVIR AND DARUNAVIR INTERMEDIATES | MAPI PHARMA LIMITED (IL) | 2012-11-22 | — | — | US | disclosed |
| WO-2011092687-A1 | PROCESS FOR THE PREPARATION OF DARUNAVIR AND DARUNAVIR INTERMEDIATES | MAPI PHARMA HK LIMITED (CN) | 2011-08-04 | — | — | WO | disclosed |
| CN-1989122-A | Novel cyclopenta [ b ] benzofuran derivatives and uses thereof | BAYER HEALTHCARE AG (DE) | 2007-06-27 | — | — | CN | disclosed |
| CN-1246319-C | Amino (thio) ether derivative | MERCK PATENT AG (DE) | 2006-03-22 | — | — | CN | disclosed |
| EP-0711773-B1 | HYMENIALDISINE AND DERIVATIVE THEREOF, PROCESS FOR PRODUCING INTERMEDIATE FOR SYNTHESIZING THE SAME, AND SAID INTERMEDIATE | SUNTORY LTD (JP) | 2001-09-12 | — | — | EP | disclosed |
| EP-1123933-A1 | 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chromane as CNS active agent | MERCK PATENT GmbH (DE) | 2001-08-16 | — | — | EP | disclosed |
| CN-1055288-C | Cation-sensitive composite structures and compounds for use therein | MINNESOTA MINING & MFG (US) | 2000-08-09 | — | — | CN | disclosed |
| US-5767132-A | CENTRAL NERVOUS SYSTEM | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-06-16 | — | — | US | disclosed |
| US-5621099-A | CARDIOVASCULAR DISORDERS | SUNTORY LIMITED (JP) | 1997-04-15 | — | — | US | disclosed |
| CN-1130180-A | Amino (thio) ether derivative | MERCK PATENT AG (DE) | 1996-09-04 | — | — | CN | disclosed |
| EP-0711773-A1 | HYMENIALDISINE AND DERIVATIVE THEREOF, PROCESS FOR PRODUCING INTERMEDIATE FOR SYNTHESIZING THE SAME, AND SAID INTERMEDIATE | SUNTORY LIMITED (JP) | 1996-05-15 | — | — | EP | disclosed |
| EP-0707007-A1 | Amino(thio)ether derivatives as CNS active agents | MERCK PATENT GmbH (DE) | 1996-04-17 | — | — | EP | disclosed |
| CN-1106407-A | Cation-sensitive composite structures and compounds for use therein | MINNESOTA MINING & MFG (US) | 1995-08-09 | — | — | CN | disclosed |
| EP-0342568-B1 | Heterocyclically substituted phenoxysulfonyl urea, process for their preparation and their use as herbicides or as plant growth regulators | HOECHST AG (DE) | 1994-02-02 | — | — | EP | disclosed |
| US-5102443-A | Free-and postemergenc herbicides | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-04-07 | — | — | US | disclosed |
| EP-0342568-A1 | Heterocyclically substituted phenoxysulfonyl urea, process for their preparation and their use as herbicides or as plant growth regulators | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120296101-A1 | PROCESS FOR THE PREPARATION OF DARUNAVIR AND DARUNAVIR INTERMEDIATES | CYP3A43, CYP3A4, DHPS | GAA 645/4885JAK2 3909/4885LMNA 4206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.