Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF3 | O95398 | 13/20 | 0.74 |
| ▸ | RAPGEF4 | Q8WZA2 | 9/20 | 0.74 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | HTT | P42858 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | NPY1R | P25929 | 1/20 | 0.62 |
| ▸ | NPY2R | P49146 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL922713 | 0.86 | MAPT (0.81) | RAPGEF3RAPGEF4MAPTHTTSMN1; SMN2 | |
| SCHEMBL922712 | 0.86 | MAPT (0.81) | RAPGEF3RAPGEF4MAPTHTTSMN1; SMN2 | |
| SCHEMBL20523642 | 0.86 | RAPGEF3 (1.00) | RAPGEF3RAPGEF4MAPTHTTSMN1; SMN2 | |
| SCHEMBL20523638 | 0.84 | RAPGEF3 (1.00) | RAPGEF3RAPGEF4MAPTHTTSMN1; SMN2 | |
| SCHEMBL20523678 | 0.83 | RAPGEF3 (1.00) | RAPGEF3RAPGEF4MAPTNPSR1 | |
| SCHEMBL20523696 | 0.83 | RAPGEF3 (1.00) | RAPGEF3RAPGEF4 | |
| SCHEMBL20523759 | 0.83 | RAPGEF3 (1.00) | RAPGEF3RAPGEF4MAPTHTTSMN1; SMN2 | |
| SCHEMBL20523682 | 0.79 | RAPGEF3 (1.00) | RAPGEF3RAPGEF4MAPTHTTSMN1; SMN2 | |
| SCHEMBL20523659 | 0.79 | RAPGEF3 (1.00) | RAPGEF3RAPGEF4MAPTHTTSMN1; SMN2 | |
| SCHEMBL20523703 | 0.78 | RAPGEF3 (1.00) | RAPGEF3RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11124489-B2 | EPAC antagonists | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-09-21 | — | — | US | disclosed |
| US-20200255388-A1 | EPAC ANTAGONISTS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255388-A1 | EPAC ANTAGONISTS | EPAS1, GPR139, CRACR2A | RAPGEF3 5/4885RAPGEF4 7/4885MAPT 4650/4885 |
| US-11124489-B2 | EPAC antagonists | EPAS1, GPR139, CRACR2A | RAPGEF3 5/4885RAPGEF4 7/4885MAPT 4650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.