Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | PDE8B | O95263 | 3/20 | 0.38 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.35 |
| ▸ | PDE4A | P27815 | 5/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22340999 | 1.00 | PDE10A (0.42) | PDE10APDE8BTDP2CHRM3PDE4A | |
| SCHEMBL22340924 | 0.82 | TDP2 (0.38) | PDE10ATDP2CHRM3PDE4APDE4B | |
| SCHEMBL22341027 | 0.82 | TDP2 (0.38) | PDE10ATDP2CHRM3PDE4APDE4B | |
| SCHEMBL22340274 | 0.82 | TDP2 (0.38) | PDE10ATDP2CHRM3PDE4APDE4B | |
| SCHEMBL28147887 | 0.77 | PDE10A (0.55) | PDE10APDE8BCHRM3PDE4APDE4B | |
| SCHEMBL27846371 | 0.70 | PDE10A (0.83) | PDE10APDE8BCHRM3PDE4APDE4B | |
| SCHEMBL21306205 | 0.67 | HRH2 (0.33) | PDE8BTDP2CHRM3PDE4APDE4B | |
| SCHEMBL6396181 | 0.66 | CHRM3 (0.43) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL18383786 | 0.66 | HRH2 (0.43) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL4838901 | 0.66 | HRH2 (0.43) | PDE10ACHRM3PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020163405-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. (US) | 2020-08-13 | — | — | WO | disclosed |
| WO-2020163401-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. (US) | 2020-08-13 | — | — | WO | disclosed |