Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22525950 | 0.89 | KDM4E (0.59) | KDM4EMAPK1HIF1APAOXMEN1 | |
| SCHEMBL12123508 | 0.89 | CES2 (0.53) | KDM4EMAPK1HIF1APAOXMEN1 | |
| SCHEMBL23560302 | 0.89 | KDM4E (0.59) | KDM4EMAPK1HIF1APAOXMEN1 | |
| SCHEMBL24340726 | 0.89 | CES2 (0.53) | KDM4EMAPK1HIF1APAOXMEN1 | |
| SCHEMBL8545916 | 0.89 | CES2 (0.53) | KDM4EMAPK1HIF1APAOXMEN1 | |
| SCHEMBL5693542 | 0.87 | KDM4E (0.61) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL5155263 | 0.87 | MEN1 (0.56) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL19309079 | 0.87 | MEN1 (0.56) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL22340561 | 0.87 | KDM4E (0.48) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL22340558 | 0.87 | KDM4E (0.48) | KDM4EMAPK1HIF1APAOXADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020162725-A1 | TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT | 한국화학연구원 | 2020-08-13 | — | — | WO | disclosed |