Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CASP2 | P42575 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22340557 | 0.87 | KDM4E (0.64) | KDM4EMAPK1HIF1APAOXEPHX2 | |
| SCHEMBL21765847 | 0.85 | KDM4E (0.67) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL14981894 | 0.85 | KDM4E (0.67) | KDM4EMAPK1HIF1APAOXADRA1A | |
| SCHEMBL14669876 | 0.84 | TSHR (0.46) | EPHX2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13311547 | 0.83 | MEN1 (0.48) | KDM4EEPHX2MEN1KMT2AL3MBTL1 | |
| SCHEMBL22374761 | 0.83 | FAAH (0.38) | EPHX2CYP2C19MEN1KMT2AFAAH | |
| SCHEMBL13864736 | 0.83 | EPHX2 (0.48) | EPHX2MEN1KMT2AFAAHCASP2 | |
| SCHEMBL22845257 | 0.83 | EPHX2 (0.48) | EPHX2MEN1KMT2AFAAHCASP2 | |
| SCHEMBL12037859 | 0.82 | MAPK1 (0.50) | KDM4EMAPK1HIF1APAOXEPHX2 | |
| SCHEMBL22340559 | 0.82 | KDM4E (0.61) | KDM4EMAPK1HIF1APAOXEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020162725-A1 | TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT | 한국화학연구원 | 2020-08-13 | — | — | WO | disclosed |