Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.62 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.62 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.62 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14307268 | 0.82 | PDE4A (0.74) | KMT2AMEN1ALDH1A1KDM4EPDK1 | |
| SCHEMBL3618299 | 0.80 | ALDH1A1 (0.55) | KMT2AMEN1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL13317262 | 0.80 | ALDH1A1 (0.55) | KMT2AMEN1ALDH1A1KDM4EPDK1 | |
| SCHEMBL11948287 | 0.78 | ALDH1A1 (0.63) | KMT2AMEN1ALDH1A1KDM4EPDK1 | |
| SCHEMBL27438746 | 0.78 | ALDH1A1 (0.60) | KMT2AMEN1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7021322 | 0.78 | PDE4A (0.55) | KMT2AMEN1ALDH1A1KDM4EPDK1 | |
| SCHEMBL18773823 | 0.77 | ALDH1A1 (0.70) | KMT2AMEN1ALDH1A1KDM4EPDK1 | |
| SCHEMBL7019317 | 0.77 | KDM4E (0.55) | KMT2AMEN1ALDH1A1KDM4EPDK1 | |
| SCHEMBL16589864 | 0.77 | PDK1 (1.00) | ALDH1A1PDK1PDK2PDK3PDK4 | |
| SCHEMBL156256 | 0.76 | NOTUM (0.82) | KMT2AMEN1ALDH1A1KDM4EPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020163236-A1 | TREATING LONG QT SYNDROME | THE GENERAL HOSPITAL CORPORATION (US) | 2020-08-13 | — | — | WO | disclosed |