Sugi Predict

Sugi Predict / Compounds / SCHEMBL223411

SCHEMBL223411

SCHEMBL223411

O=Cc1cccc(Cl)c1F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.50
▸ MEN1 O00255 3/20 0.50
▸ KMT2A Q03164 3/20 0.50
▸ TDP1 Q9NUW8 3/20 0.50
▸ ERN1 O75460 3/20 0.47
▸ LMNA P02545 1/20 0.46
▸ THRB P10828 1/20 0.46
▸ BLM P54132 1/20 0.46
▸ HTT P42858 2/20 0.42
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ TSHR P16473 1/20 0.38
▸ TRIM24 O15164 1/20 0.38
▸ TRIM33 Q9UPN9 1/20 0.38
▸ IDO1 P14902 1/20 0.37
▸ KAT2B Q92831 1/20 0.37
▸ CYP2A6 P11509 2/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ HPGD P15428 1/20 0.34
▸ TLR2 O60603 1/20 0.34
▸ TLR1 Q15399 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29512764 1.00 ALDH1A1 (0.50) ALDH1A1MEN1KMT2ATDP1ERN1
SCHEMBL3452799 0.86 ALDH1A1 (0.41) ALDH1A1MEN1KMT2ATDP1LMNA
SCHEMBL6853865 0.83 KMT2A (0.58) ALDH1A1MEN1KMT2ATDP1ERN1
SCHEMBL18345581 0.79 CDK4 (0.46) ALDH1A1MEN1KMT2ATDP1ERN1
SCHEMBL18345584 0.79 CDK4 (0.46) ALDH1A1MEN1KMT2ATDP1ERN1
SCHEMBL19236964 0.79 ALDH1A1 (0.39) ALDH1A1MEN1KMT2ATDP1LMNA
SCHEMBL17842843 0.79 TDP1 (0.46) ALDH1A1MEN1KMT2ATDP1ERN1
SCHEMBL9245053 0.77 ALDH1A1 (0.60) ALDH1A1MEN1KMT2ATDP1LMNA
SCHEMBL16953070 0.77 ALDH1A1 (0.38) ALDH1A1MEN1KMT2ATDP1ERN1
SCHEMBL5412830 0.77 CFD (0.39) ALDH1A1MEN1KMT2ATDP1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 853 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114907335-A 2- (benzothiophene-2-yl) benzo [ d ] oxazole derivative, preparation method and application 陕西维世诺新材料有限公司 2022-08-16 — — CN claimed
CN-109651375-B Tetrahydroquinazoline derivative and synthesis method and application thereof 上海应用技术大学 2020-10-09 — — CN claimed
CN-109651375-A A kind of tetrahydro quinazoline derivative and its synthetic method and application 上海应用技术大学 2019-04-19 — — CN claimed
CN-109312618-A For hydraulic fracturing and for the method and composition of tracer water flooding 光谱追踪服务有限责任公司 2019-02-05 — — CN claimed
CN-104529729-B The preparation method of the fluoro-3-chlorobenzaldehyde of a kind of 2- ZHEJIANG YONGTAI TECHNOLOGY CO., LTD. (CN) 2016-03-30 — — CN claimed
EP-2190804-B1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS GILEAD SCIENCES INC (US) 2015-11-18 — — EP claimed
CN-104529729-A Preparation method for 2-fluoro-3-chlorobenzaldehyde ZHEJIANG YONGTAI TECHNOLOGY CO LTD 2015-04-22 — — CN claimed
EP-2069280-B1 Process and intermediates for preparing HIV integrase inhibitors GILEAD SCIENCES INC (US) 2015-03-25 — — EP claimed
CN-101821223-B Process and intermediates for preparing integrase inhibitors GILEAD SCIENCES INC 2014-07-09 — — CN claimed
CN-101516819-B Process and intermediates for preparing integrase inhibitors GILEAD SCIENCES INC 2013-10-16 — — CN claimed
US-20100292480-A1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS GILEAD SCIENCES, INC (US) 2010-11-18 — — US claimed
US-7825252-B2 Process and intermediates for preparing integrase inhibitors GILEAD SCIENCES, INC. (US) 2010-11-02 — — US claimed
CN-101821223-A Process and intermediates for preparing integrase inhibitors GILEAD SCIENCES INC 2010-09-01 — — CN claimed
EP-2190804-A1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS Gilead Sciences, Inc. (US) 2010-06-02 — — EP claimed
CN-101516819-A Process and intermediates for preparing integrase inhibitors GILEAD SCIENCES INC (US) 2009-08-26 — — CN claimed
EP-2069280-A2 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS Gilead Sciences, Inc. (US) 2009-06-17 — — EP claimed
US-20090099366-A1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS GILEAD SCIENCES, INC. (US) 2009-04-16 — — US claimed
WO-2009036161-A1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS GILEAD SCIENCES, INC. (US) 2009-03-19 — — WO claimed
US-20080125594-A1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS GILEAD SCIENCES, INC. (US) 2008-05-29 — — US claimed
WO-2008033836-A2 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS GILEAD SCIENCES, INC. (US) 2008-03-20 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090099366-A1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS TYMS, TYMP, POLB ALDH1A1 2138/4885MEN1 3105/4885KMT2A 1100/4885
US-20080125594-A1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS TYMS, TYMP, POLB ALDH1A1 2138/4885MEN1 3105/4885KMT2A 1100/4885
US-20100292480-A1 PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS TYMS, TYMP, POLB ALDH1A1 2138/4885MEN1 3105/4885KMT2A 1100/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.