Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.31 |
| ▸ | TPMT | P51580 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA6 | P23280 | 1/20 | 0.30 |
| ▸ | NQO2 | P16083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27628106 | 0.83 | CA2 (0.43) | CA2CA4ACHEALOX5APFEN1 | |
| SCHEMBL27628234 | 0.83 | CA2 (0.39) | CA2CA4ACHEIMPDH2ALOX5AP | |
| SCHEMBL31015964 | 0.83 | CA2 (0.41) | CA2CA4ALOX5APFEN1HSD17B10 | |
| SCHEMBL9377977 | 0.83 | CA2 (0.41) | CA2CA4ALOX5APFEN1HSD17B10 | |
| SCHEMBL16256381 | 0.80 | ACHE (0.36) | ACHEALDH1A1TUBB1 | |
| SCHEMBL4589673 | 0.78 | CA2 (0.46) | CA2CA4ALOX5APFEN1HSD17B10 | |
| SCHEMBL9549445 | 0.78 | CA2 (0.38) | CA2CA4ALOX5APFEN1HSD17B10 | |
| SCHEMBL22831899 | 0.78 | MAPT (0.38) | CA2CA4ALOX5APFEN1HSD17B10 | |
| SCHEMBL525151 | 0.77 | CA2 (0.50) | CA2CA4ACHEIMPDH2ALOX5AP | |
| SCHEMBL15510333 | 0.76 | CA2 (0.36) | CA2CA4ACHEIMPDH2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484878-B1 | BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2020-08-19 | — | — | EP | disclosed |