Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | AHCY | P23526 | 2/20 | 0.39 |
| ▸ | NT5E | P21589 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | GNMT | Q14749 | 2/20 | 0.38 |
| ▸ | ADH1A | P07327 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22343537 | 0.91 | BCHE (0.46) | BCHEAHCYNT5EDOT1LEGFR | |
| SCHEMBL22343667 | 0.90 | BCHE (0.46) | BCHEAHCYNT5ECYP1A2DOT1L | |
| SCHEMBL22343637 | 0.89 | BCHE (0.46) | BCHEAHCYNT5EGNMT | |
| SCHEMBL22343707 | 0.89 | BCHE (0.46) | BCHEAHCYNT5EGNMT | |
| SCHEMBL22343765 | 0.87 | BCHE (0.42) | BCHEAHCYNT5EEGFRGNMT | |
| SCHEMBL22343664 | 0.86 | BCHE (0.44) | BCHEAHCYNT5ECYP1A2DOT1L | |
| SCHEMBL22343609 | 0.86 | BCHE (0.44) | BCHEAHCYNT5ECYP1A2DOT1L | |
| SCHEMBL22343675 | 0.84 | ADH1A (0.53) | GNMTADH1A | |
| SCHEMBL22343650 | 0.81 | BCHE (0.45) | BCHEAHCYNT5ECYP1A2EGFR | |
| SCHEMBL22343649 | 0.81 | BCHE (0.45) | BCHEAHCYNT5ECYP1A2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020163673-A1 | INHIBITORS OF ADENYLATE-FORMING ENZYME MENE | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2020-08-13 | — | — | WO | disclosed |