Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 18/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21326696 | 0.83 | IRAK4 (0.51) | IRAK4 | |
| SCHEMBL29773937 | 0.82 | IRAK4 (0.37) | IRAK4 | |
| SCHEMBL21326611 | 0.80 | IRAK4 (0.46) | IRAK4KDM4EALDH1A1 | |
| SCHEMBL21326651 | 0.76 | IRAK4 (0.51) | IRAK4KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL21326669 | 0.75 | IRAK4 (0.52) | IRAK4 | |
| SCHEMBL21326705 | 0.75 | IRAK4 (0.51) | IRAK4 | |
| SCHEMBL21326725 | 0.74 | IRAK4 (0.56) | IRAK4 | |
| SCHEMBL21326720 | 0.71 | IRAK4 (0.42) | IRAK4KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL23093807 | 0.70 | CYP1A2 (0.43) | IRAK4MEN1ALDH1A1KMT2A | |
| SCHEMBL21326692 | 0.69 | IRAK4 (0.51) | IRAK4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200262845-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | GENENTECH, INC. (US) | 2020-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200262845-A1 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | IRAK4 1/4885KDM4E 674/4885MEN1 4121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.