Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 15/20 | 0.37 |
| ▸ | OGA | O60502 | 3/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22344222 | 0.82 | IRAK4 (0.38) | IRAK4 | |
| SCHEMBL21326705 | 0.81 | IRAK4 (0.51) | IRAK4GAA | |
| SCHEMBL21326611 | 0.81 | IRAK4 (0.46) | IRAK4GAA | |
| SCHEMBL29773991 | 0.81 | IRAK4 (0.37) | IRAK4OGA | |
| SCHEMBL21326651 | 0.80 | IRAK4 (0.51) | IRAK4 | |
| SCHEMBL21326725 | 0.78 | IRAK4 (0.56) | IRAK4 | |
| SCHEMBL21326696 | 0.77 | IRAK4 (0.51) | IRAK4 | |
| SCHEMBL21326669 | 0.76 | IRAK4 (0.52) | IRAK4 | |
| SCHEMBL21326720 | 0.74 | IRAK4 (0.42) | IRAK4 | |
| SCHEMBL23093807 | 0.71 | CYP1A2 (0.43) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109890829-B | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2022-07-15 | — | — | CN | disclosed |