Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28051580 | 0.85 | TTR (0.44) | FOLH1HTTHPGDTDP1KDM4E | |
| SCHEMBL976882 | 0.85 | FOLH1 (0.46) | FOLH1HTTHPGDTDP1KDM4E | |
| SCHEMBL21821510 | 0.84 | APEX1 (0.44) | FOLH1HTTHPGDTDP1KDM4E | |
| SCHEMBL3199979 | 0.84 | RXRA (0.43) | FOLH1HTTHPGDTDP1KDM4E | |
| SCHEMBL27785149 | 0.83 | FOLH1 (0.45) | FOLH1HTTHPGDTDP1KDM4E | |
| SCHEMBL27885537 | 0.82 | TSHR (0.44) | KDM4ECA12CA1CA2POLB | |
| SCHEMBL10742292 | 0.82 | FOLH1 (0.42) | FOLH1HTTHPGDTDP1KDM4E | |
| SCHEMBL3893054 | 0.81 | FOLH1 (0.43) | FOLH1HTTHPGDTDP1KDM4E | |
| SCHEMBL1176410 | 0.81 | ALDH1A1 (0.50) | FOLH1HTTHPGDTDP1KDM4E | |
| SCHEMBL1073276 | 0.81 | KDM4E (0.47) | FOLH1TDP1KDM4ECA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2534154-A1 | MACROCYCLES AS FACTOR XIA INHIBITORS | Bristol-Myers Squibb Company (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100401-A1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-08-18 | — | — | WO | disclosed |