Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 3/20 | 0.40 |
| ▸ | METAP1 | P53582 | 3/20 | 0.40 |
| ▸ | GPR88 | Q9GZN0 | 4/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CFD | P00746 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HAT1 | O14929 | 2/20 | 0.36 |
| ▸ | EP300 | Q09472 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22069911 | 0.97 | RIPK1 (0.44) | RIPK1METAP2METAP1GPR88GLA | |
| SCHEMBL22069921 | 0.84 | GLA (0.47) | GLAKDM4EALDH1A1 | |
| SCHEMBL22069920 | 0.84 | GLA (0.47) | GLAKDM4EALDH1A1 | |
| SCHEMBL22069913 | 0.82 | GLA (0.40) | RIPK1GLAKDM4EAPAF1ALDH1A1 | |
| SCHEMBL22309192 | 0.82 | GLA (0.40) | RIPK1GLAKDM4EAPAF1ALDH1A1 | |
| SCHEMBL22070173 | 0.73 | IMPDH2 (0.36) | RIPK1GLAKDM4EAPAF1HAT1 | |
| SCHEMBL31026915 | 0.73 | IMPDH2 (0.36) | RIPK1GLAKDM4EAPAF1HAT1 | |
| SCHEMBL20738926 | 0.73 | IMPDH2 (0.36) | RIPK1GLAKDM4EAPAF1HAT1 | |
| SCHEMBL22069885 | 0.72 | GLA (0.45) | GLAALDH1A1 | |
| SCHEMBL22069886 | 0.68 | GLA (0.45) | GLAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020166592-A1 | HEMIASTERLIN DERIVATIVE AND ANTIBODY-DRUG CONJUGATE THEREOF | 大日本住友製薬株式会社 | 2020-08-20 | — | — | WO | disclosed |
| WO-2020166600-A1 | HEMIASTERLIN DERIVATIVE HAVING CYSTEINE RESIDUE | 大日本住友製薬株式会社 | 2020-08-20 | — | — | WO | disclosed |