Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 4/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HSD17B14 | Q9BPX1 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20772073 | 0.86 | MGAM (0.53) | MGAMKMOKDM4EALOX15TSHR | |
| SCHEMBL2715968 | 0.86 | MGAM (0.53) | MGAMKMOKDM4EALOX15TSHR | |
| SCHEMBL18191203 | 0.80 | MGAM (0.47) | MGAMKDM4EALOX15TSHRACMSD | |
| SCHEMBL12405037 | 0.80 | MGAM (0.63) | MGAMKDM4EALOX15TSHRACMSD | |
| SCHEMBL29411763 | 0.78 | MGAM (0.49) | MGAMKDM4EALOX15TSHRACMSD | |
| SCHEMBL26606765 | 0.78 | MGAM (0.49) | MGAMKDM4EALOX15TSHRACMSD | |
| SCHEMBL9220609 | 0.78 | MGAM (0.61) | MGAMKDM4EALOX15TSHRACMSD | |
| SCHEMBL22777233 | 0.75 | MGAM (0.58) | MGAMKMOKDM4EALOX15TSHR | |
| SCHEMBL7170725 | 0.75 | MGAM (0.58) | MGAMKMOKEAP1KDM4EALOX15 | |
| SCHEMBL29527233 | 0.75 | MGAM (0.58) | MGAMKMOKDM4EALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11958840-B2 | Compounds, compositions and methods | DENALI THERAPEUTICS INC. (US) | 2024-04-16 | — | — | US | disclosed |
| US-20230114472-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. | 2023-04-13 | — | — | US | disclosed |
| US-11306077-B2 | Compounds, compositions and methods | DENALI THERAPEUTICS INC. (US) | 2022-04-19 | — | — | US | disclosed |
| EP-3923935-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | Denali Therapeutics Inc. (US) | 2021-12-22 | — | — | EP | disclosed |
| CN-113518618-A | Compounds, compositions and methods | 戴纳立制药公司 | 2021-10-19 | — | — | CN | disclosed |
| US-20210292311-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. | 2021-09-23 | — | — | US | disclosed |
| WO-2020168011-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2020-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11958840-B2 | Compounds, compositions and methods | EIF4EBP1, EIF4B, EIF4E | MGAM 4178/4885KMO 4531/4885NR1H4 1736/4885 |
| US-20230114472-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | EIF4EBP1, EIF4B, EIF4E | MGAM 4178/4885KMO 4531/4885NR1H4 1736/4885 |
| US-20210292311-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | EIF4EBP1, EIF4B, EIF4E | MGAM 4178/4885KMO 4531/4885NR1H4 1736/4885 |
| US-11306077-B2 | Compounds, compositions and methods | EIF4EBP1, EIF4B, EIF4E | MGAM 4178/4885KMO 4531/4885NR1H4 1736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.