Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 12/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30503503 | 1.00 | TLR7 (0.50) | TLR7CYP3A4ADORA2AADORA2BCYP2D6 | |
| SCHEMBL2060324 | 0.88 | TLR7 (0.51) | TLR7CYP3A4ADORA2AADORA2B | |
| SCHEMBL7204649 | 0.87 | TLR7 (0.64) | TLR7ADORA2A | |
| SCHEMBL4129389 | 0.85 | TLR7 (0.48) | TLR7CYP3A4CYP2D6 | |
| SCHEMBL7211348 | 0.84 | TLR7 (0.60) | TLR7ADORA2A | |
| SCHEMBL23422260 | 0.84 | TLR7 (0.48) | TLR7CYP3A4ADORA2A | |
| SCHEMBL24366542 | 0.84 | TLR7 (0.62) | TLR7 | |
| SCHEMBL2060294 | 0.83 | ALDH1A1 (0.47) | TLR7CYP3A4ADORA2AADORA2B | |
| SCHEMBL25511867 | 0.83 | MEN1 (0.51) | TLR7ADORA2A | |
| SCHEMBL4133313 | 0.83 | TLR7 (0.57) | TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116457023-A | antibody-TLR agonist conjugates, methods and uses thereof | AMBRX公司 | 2023-07-18 | — | — | CN | disclosed |
| EP-3923991-A1 | COMPOSITIONS CONTAINING, METHODS AND USES OF ANTIBODY-TLR AGONIST CONJUGATES | Ambrx, Inc. (US) | 2021-12-22 | — | — | EP | disclosed |
| CN-113660957-A | Compositions, methods, and uses comprising antibody-TLR agonist conjugates | AMBRX公司 | 2021-11-16 | — | — | CN | disclosed |
| WO-2020168017-A1 | COMPOSITIONS CONTAINING, METHODS AND USES OF ANTIBODY-TLR AGONIST CONJUGATES | AMBRX, INC. (US) | 2020-08-20 | — | — | WO | disclosed |