Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24602586 | 0.73 | CNR2 (0.37) | KMT2AMEN1 | |
| SCHEMBL24258699 | 0.70 | MAPT (0.39) | MAPTSMN1; SMN2TSHR | |
| SCHEMBL24258740 | 0.69 | L3MBTL1 (0.39) | LMNAKMT2AMEN1GAA | |
| SCHEMBL29272968 | 0.69 | SLC13A5 (0.46) | HTTMAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL24258885 | 0.67 | CNR1 (0.31) | SMN1; SMN2TP53TSHR | |
| SCHEMBL24258911 | 0.67 | GAA (0.40) | LMNAKDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL3425284 | 0.64 | GAA (0.50) | HTTLMNASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL15958824 | 0.64 | KMT2A (0.47) | HTTMAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL1255409 | 0.64 | SLC13A5 (0.47) | HTTMAPTLMNASMN1; SMN2TP53 | |
| SCHEMBL7291045 | 0.62 | KEAP1 (0.52) | LMNASMN1; SMN2KDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020168152-A2 | SUBSTITUTED AMIDE COMPOUNDS USEFUL AS FARNESOID X RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-08-20 | — | — | WO | disclosed |