SCHEMBL2235161

SCHEMBL2235161

NC(=O)Nc1ccc(S)cc1

nearest known ligand 0.64

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PEPD P12955 1/20 0.64
ALDH1A1 P00352 3/20 0.61
NPC1 O15118 1/20 0.61
MAPT P10636 2/20 0.57
GAA P10253 1/20 0.57
GFER P55789 1/20 0.57
KIF11 P52732 9/20 0.55
MEN1 O00255 1/20 0.55
LMNA P02545 1/20 0.55
KMT2A Q03164 1/20 0.55
GLA P06280 1/20 0.50
HSD17B10 Q99714 1/20 0.47
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5062623 0.87 PEPD (0.80) PEPDALDH1A1NPC1MAPTGAA
SCHEMBL8379303 0.81 PEPD (0.64) PEPDALDH1A1NPC1MAPTGAA
SCHEMBL11567760 0.81 PEPD (0.64) PEPDALDH1A1NPC1MAPTGAA
SCHEMBL1322717 0.78 PEPD (1.00) PEPDALDH1A1NPC1MAPTGAA
SCHEMBL6879129 0.78 MAPT (0.70) PEPDALDH1A1NPC1MAPTGAA
SCHEMBL5536751 0.78 PEPD (0.67) PEPDALDH1A1NPC1MAPTGAA
SCHEMBL1532333 0.78 TDP1 (0.43) NPC1MAPTGAAGFERHSD17B10
SCHEMBL2755848 0.76 PEPD (0.64) PEPDALDH1A1NPC1MAPTGAA
SCHEMBL6938372 0.76 PEPD (0.64) PEPDALDH1A1NPC1MAPTGAA
SCHEMBL272215 0.76 SMN1; SMN2 (0.67) ALDH1A1NPC1MAPTGAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10444220-B2 Controlled tunnel gap device for sequencing polymers ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-10-15 US claimed
US-20180224422-A1 CONTROLLED TUNNEL GAP DEVICE FOR SEQUENCING POLYMERS ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2018-08-09 US claimed
US-9810681-B2 Controlled tunnel gap device for sequencing polymers ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2017-11-07 US claimed
US-20160097759-A1 CONTROLLED TUNNEL GAP DEVICE FOR SEQUENCING POLYMERS ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2016-04-07 US claimed
US-9140682-B2 Controlled tunnel gap device for sequencing polymers ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2015-09-22 US claimed
US-20120288948-A1 CONTROLLED TUNNEL GAP DEVICE FOR SEQUENCING POLYMERS ARIZONA BOARD OF REGENTS (US) 2012-11-15 US claimed
EP-2517028-A1 CONTROLLED TUNNEL GAP DEVICE FOR SEQUENCING POLYMERS Arizona Board Of Regents (US) 2012-10-31 EP claimed
WO-2011097171-A1 CONTROLLED TUNNEL GAP DEVICE FOR SEQUENCING POLYMERS ARIZONA BOARD OF REGENTS (US) 2011-08-11 WO claimed
US-11673136-B2 Nanopore devices for sensing biomolecules ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2023-06-13 US disclosed
US-20210389296-A1 NON-HYDROGEN-BONDING UNIVERSAL READER FOR DNA SEQUENCING ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2021-12-16 US disclosed
US-11119089-B2 Non-hydrogen-bonding universal reader for DNA sequencing ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA (US) 2021-09-14 US disclosed
US-10444220-B2 Controlled tunnel gap device for sequencing polymers ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-10-15 US disclosed
US-20190250127-A1 TRANSLOCATION OF A NON-NUCLEIC ACID POLYMER USING A POLYMERASE ALTEK EUROPE LIMITED (GB) 2019-08-15 US disclosed
EP-3519802-A1 TRANSLOCATION OF A NON-NUCLEIC ACID POLYMER USING A POLYMERASE Arizona Board of Regents on behalf of Arizona State University (US) 2019-08-07 EP disclosed
US-4003906-A Substituted pyridinyl methylthio or (methylsulfonyl)benzeneamines THE DOW CHEMICAL COMPANY (US) 1977-01-18 US disclosed
US-4001234-A SUBSTITUTED PYRIMIDINYLOXY(THIO)PHENYL UREAS AND DERIVATIVES THEREOF THE DOW CHEMICAL COMPANY (US) 1977-01-04 US disclosed
US-3991068-A Substituted pyridinylalkoxy-, pyridinylalkylsulfonyl- and pyridinylalkylthiophenylureas THE DOW CHEMICAL COMPANY (US) 1976-11-09 US disclosed
US-3987050-A SUBSTITUTED PYRIDINYLALKOXY-, PYRIDINYLALKYLSULFONYL AND PYRIDINYLALKYLTHIO-PHENYL-LOWER-ALKANAMIDES THE DOW CHEMICAL COMPANY (US) 1976-10-19 US disclosed
US-3947437-A Substituted pyridazinyloxy(thio)phenyl ureas and derivatives thereof THE DOW CHEMICAL COMPANY (US) 1976-03-30 US disclosed
US-3931200-A Substituted pyridinylalkoxy-, pyridinylalkylsulfonyl- and pyridinylalkylthio- phenylureas THE DOW CHEMICAL COMPANY (US) 1976-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210389296-A1 NON-HYDROGEN-BONDING UNIVERSAL READER FOR DNA SEQUENCING DNMT3A, ADAR, UNG PEPD 2940/4885ALDH1A1 3207/4885NPC1 4675/4885
US-11119089-B2 Non-hydrogen-bonding universal reader for DNA sequencing DNMT3A, ADAR, UNG PEPD 2940/4885ALDH1A1 3207/4885NPC1 4675/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.