SCHEMBL2235285

SCHEMBL2235285

COC(=O)/C(O)=C/C(=O)c1ccc(Cl)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.50
POLB P06746 1/20 0.50
ALDH1A1 P00352 4/20 0.47
MAPT P10636 5/20 0.46
NPC1 O15118 3/20 0.46
LMNA P02545 2/20 0.46
RAB9A P51151 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
MAOB P27338 3/20 0.45
MAOA P21397 2/20 0.45
HPGD P15428 3/20 0.45
CYP1A2 P05177 3/20 0.45
CYP2C19 P33261 3/20 0.45
ALOX12 P18054 1/20 0.45
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44
CYP1B1 Q16678 1/20 0.44
HTT P42858 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2235288 1.00 GAA (0.50) GAAPOLBALDH1A1MAPTNPC1
SCHEMBL2231488 0.84 ALDH1A1 (0.60) GAAALDH1A1MAPTNPC1LMNA
SCHEMBL2231484 0.84 ALDH1A1 (0.60) GAAALDH1A1MAPTNPC1LMNA
SCHEMBL28547583 0.84 GAA (0.48) GAAPOLBALDH1A1MAPTNPC1
SCHEMBL3310563 0.84 NFE2L2 (0.53) GAAPOLBALDH1A1MAPTNPC1
SCHEMBL2232374 0.84 NFE2L2 (0.53) GAAPOLBALDH1A1MAPTNPC1
SCHEMBL2232370 0.84 NFE2L2 (0.53) GAAPOLBALDH1A1MAPTNPC1
SCHEMBL3310551 0.83 ALDH1A1 (0.51) GAAALDH1A1MAPTNPC1LMNA
SCHEMBL2234643 0.83 CYP1A2 (0.61) ALDH1A1MAPTNPC1LMNARAB9A
SCHEMBL2234650 0.83 CYP1A2 (0.61) ALDH1A1MAPTNPC1LMNARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3459945-A1 BCL-2/BCL-XL INHIBITORS FOR USE IN THE TREATMENT OF CANCER The Regents of The University of Michigan (US) 2019-03-27 EP disclosed
EP-2668180-B1 BCL-2/BCL-XL INHIBITORS FOR USE IN THE TREATMENT OF CANCER UNIV MICHIGAN REGENTS (US) 2018-08-01 EP disclosed
WO-2012103059-A2 BCL-2/BCL-XL INHIBITORS AND THERAPEUTIC METHODS USING THE SAME THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2012-08-02 WO disclosed
WO-2011092505-A1 S100 PROTEIN BINDING INTERACTION INHIBITORS CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2011-08-04 WO disclosed
US-6686496-B1 4-OXO-2 BUTENOIC ACID AND 3-HYDRAZINO-2,4-DIOXOBUTANOIC ACID DERIVATIVES UNIVERSITY OF CENTRAL FLORIDA 2004-02-03 US disclosed