Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 5/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21556903 | 0.79 | IAPP (0.45) | IAPPMTNR1AMPOTAAR1CA2 | |
| SCHEMBL14868503 | 0.74 | IAPP (0.41) | IAPPMTNR1AMPOTAAR1CA2 | |
| SCHEMBL1036007 | 0.73 | IAPP (0.50) | IAPPMPOADRB2CA2ADAMTS4 | |
| SCHEMBL22353005 | 0.73 | IAPP (0.35) | IAPP | |
| SCHEMBL14868428 | 0.70 | IAPP (0.41) | IAPPMTNR1AMPOCA2CA1 | |
| SCHEMBL22353010 | 0.69 | IAPP (0.34) | IAPPCA2CA1CA12 | |
| SCHEMBL14868471 | 0.69 | IAPP (0.39) | IAPPMTNR1AMPO | |
| SCHEMBL4827827 | 0.68 | PIM1 (0.41) | IAPPMTNR1ACA2ADAMTS4ALDH1A1 | |
| SCHEMBL2468728 | 0.68 | HTR2A (0.56) | IAPPMPOTAAR1CA2ADAMTS4 | |
| SCHEMBL19710395 | 0.66 | ESR2 (0.47) | IAPPMTNR1AALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2800561-B1 | BIGUANIDE COMPOSITIONS AND METHODS OF TREATING METABOLIC DISORDERS | ANJI PHARMA US LLC (US) | 2020-08-19 | — | — | EP | disclosed |