Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | KCNJ5 | P48544 | 4/20 | 0.43 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.43 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | PRKX | P51817 | 1/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | P2RX4 | Q99571 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19552590 | 0.83 | P2RX4 (0.56) | KCNJ5KCNJ3KCNJ6P2RX4ALDH1A1 | |
| SCHEMBL22353152 | 0.78 | KCNJ5 (0.42) | ROCK2ROCK1NR1I2KCNJ5KCNJ3 | |
| SCHEMBL22353212 | 0.77 | KCNJ5 (0.49) | ROCK2ROCK1NR1I2KCNJ5KCNJ3 | |
| SCHEMBL22353144 | 0.76 | NPC1 (0.48) | ROCK2ROCK1KCNJ5KCNJ3KCNJ6 | |
| SCHEMBL22353167 | 0.76 | CLK2 (0.47) | ROCK2ROCK1NR1I2KCNJ5KCNJ3 | |
| SCHEMBL22894294 | 0.76 | P2RX4 (0.46) | ROCK2ROCK1NR1I2KCNJ5KCNJ3 | |
| SCHEMBL22353126 | 0.76 | KCNQ2 (0.46) | ROCK2ROCK1NR1I2KCNJ5KCNJ3 | |
| SCHEMBL19577034 | 0.76 | ROCK2 (0.47) | ROCK2ROCK1NR1I2KCNJ5KCNJ3 | |
| SCHEMBL22353021 | 0.75 | ROCK2 (0.45) | ROCK2ROCK1NR1I2KCNJ5KCNJ3 | |
| SCHEMBL19577035 | 0.75 | ROCK2 (0.57) | ROCK2ROCK1KCNJ5KCNJ3KCNJ6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458443-B1 | AROMATIC SULFONAMIDE DERIVATIVES | Bayer Pharma AG (DE) | 2020-08-19 | — | — | EP | disclosed |