SCHEMBL22353113

SCHEMBL22353113

O=C(Nc1ccc(-c2cnn(C(=O)O)c2)cc1)c1c(O)[nH]c(=O)[nH]c1=O

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
XDH P47989 19/20 0.62
SLC22A12 Q96S37 8/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22353089 0.77 XDH (1.00) XDHSLC22A12
SCHEMBL10926831 0.75 SLC22A12 (1.00) XDHSLC22A12
SCHEMBL16700088 0.75 XDH (1.00) XDHSLC22A12
SCHEMBL17941561 0.74 XDH (1.00) XDHSLC22A12
SCHEMBL17941585 0.74 XDH (0.65) XDHSLC22A12
SCHEMBL17010244 0.74 XDH (0.77) XDHSLC22A12
SCHEMBL17941590 0.74 XDH (0.64) XDHSLC22A12
SCHEMBL19092939 0.73 XDH (1.00) XDHSLC22A12
SCHEMBL16708623 0.73 XDH (0.78) XDHSLC22A12
SCHEMBL17010240 0.73 XDH (0.78) XDHSLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11161835-B2 Compounds and their use for reducing uric acid levels ACQUIST LLC (US) 2021-11-02 US disclosed
US-20200339545-A1 Compounds And Their Use For Reducing Uric Acid Levels ACQUIST LLC (US) 2020-10-29 US disclosed
US-10752613-B2 Compounds and their use for reducing uric acid levels ACQUIST LLC (US) 2020-08-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200339545-A1 Compounds And Their Use For Reducing Uric Acid Levels XDH, OAT, PON1 XDH 1/4885SLC22A12 327/4885
US-11161835-B2 Compounds and their use for reducing uric acid levels XDH, OAT, PON1 XDH 1/4885SLC22A12 327/4885
US-10752613-B2 Compounds and their use for reducing uric acid levels XDH, OAT, PON1 XDH 1/4885SLC22A12 327/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.