Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GPX4 | P36969 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | TNKS | O95271 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24259062 | 0.86 | ALDH1A1 (0.35) | RAB9ALMNAALDH1A1HTTKMT2A | |
| SCHEMBL24258760 | 0.83 | AKR1C4 (0.36) | L3MBTL1NR1H4MAPT | |
| SCHEMBL24258941 | 0.82 | NR1H4 (0.50) | RAB9ALMNAALDH1A1NR1H4 | |
| SCHEMBL22354184 | 0.81 | NR1H4 (0.51) | NR1H4 | |
| SCHEMBL22354110 | 0.76 | MAPT (0.36) | RAB9ALMNAALDH1A1HTTNPC1 | |
| SCHEMBL24258958 | 0.76 | NR1H4 (0.45) | NR1H4TNKSPARP1PARP2MAPT | |
| SCHEMBL24259266 | 0.76 | LMNA (0.43) | RAB9ALMNAALDH1A1HTTKMT2A | |
| SCHEMBL24259347 | 0.75 | MAPT (0.37) | RAB9ALMNAALDH1A1HTTNPC1 | |
| SCHEMBL24258902 | 0.74 | NR1H4 (0.45) | NR1H4 | |
| SCHEMBL24602597 | 0.73 | ALDH1A1 (0.42) | RAB9ALMNAALDH1A1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020168143-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-08-20 | — | — | WO | disclosed |