Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.53 |
| ▸ | KLK7 | P49862 | 2/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CPB1 | P15086 | 1/20 | 0.48 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22355258 | 0.93 | MAPT (0.54) | MAPTFOLH1KLK7KLK5ABCB1 | |
| SCHEMBL17786870 | 0.93 | SYK (0.51) | MAPTFOLH1KLK7KLK5MEN1 | |
| SCHEMBL17786872 | 0.93 | SYK (0.51) | MAPTFOLH1KLK7KLK5MEN1 | |
| SCHEMBL14719942 | 0.92 | FOLH1 (0.59) | MAPTFOLH1KLK7KLK5MMP2 | |
| SCHEMBL17287194 | 0.87 | MAPT (0.59) | MAPTKLK7KLK5MEN1KMT2A | |
| SCHEMBL18791213 | 0.87 | MAPT (0.59) | MAPTKLK7KLK5MEN1KMT2A | |
| SCHEMBL1491720 | 0.86 | FOLH1 (0.65) | MAPTFOLH1KLK7KLK5MMP2 | |
| SCHEMBL2467817 | 0.86 | FOLH1 (0.65) | MAPTFOLH1KLK7KLK5MMP2 | |
| SCHEMBL699636 | 0.86 | FOLH1 (0.65) | MAPTFOLH1KLK7KLK5MMP2 | |
| SCHEMBL23011537 | 0.86 | SYK (0.58) | MAPTKLK7KLK5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11014920-B2 | Factor XIIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-05-25 | — | — | US | disclosed |
| US-20200262831-A1 | Factor XIIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2020-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11014920-B2 | Factor XIIa inhibitors | F11, F13B, SERPINC1 | MAPT 4426/4885FOLH1 1219/4885KLK7 154/4885 |
| US-20200262831-A1 | Factor XIIa Inhibitors | F11, F13B, SERPINC1 | MAPT 4426/4885FOLH1 1219/4885KLK7 154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.