Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 20/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22346089 | 1.00 | HCRTR2 (0.89) | HCRTR2 | |
| SCHEMBL19220230 | 0.94 | HCRTR2 (1.00) | HCRTR2 | |
| SCHEMBL19219920 | 0.94 | HCRTR2 (1.00) | HCRTR2 | |
| SCHEMBL22321267 | 0.89 | HCRTR2 (0.76) | HCRTR2 | |
| SCHEMBL22321264 | 0.89 | HCRTR2 (0.76) | HCRTR2 | |
| SCHEMBL24411524 | 0.89 | HCRTR2 (0.72) | HCRTR2 | |
| SCHEMBL22346097 | 0.89 | HCRTR2 (0.72) | HCRTR2 | |
| SCHEMBL22346096 | 0.89 | HCRTR2 (0.72) | HCRTR2 | |
| SCHEMBL24284431 | 0.89 | HCRTR2 (1.00) | HCRTR2 | |
| SCHEMBL22346095 | 0.89 | HCRTR2 (0.72) | HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220144771-A1 | PYRROLIDINE OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-05-12 | — | — | US | disclosed |
| WO-2020167701-A1 | PYRROLIDINE OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2020-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144771-A1 | PYRROLIDINE OREXIN RECEPTOR AGONISTS | HCRTR2, HCRTR1, OXTR | HCRTR2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.