Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23408640 | 0.86 | PIM1 (0.40) | IRAK4PIM1DYRK3CCNT1CDK9 | |
| SCHEMBL24074245 | 0.83 | HTT (0.51) | PIM1DYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL12411738 | 0.83 | HTT (0.47) | PIM1DYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL26582556 | 0.82 | HTT (0.50) | IRAK4PIM1DYRK3CCNT1CDK9 | |
| SCHEMBL15273512 | 0.81 | PTPN11 (0.41) | PIM1DYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL1055595 | 0.79 | ALOX15 (0.51) | PIM1DYRK1AMEN1CYP1A2ALOX15 | |
| SCHEMBL13111002 | 0.79 | KDM4E (0.56) | HRH3DYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL15254681 | 0.79 | CSNK1E (0.46) | IRAK4HRH3DYRK3CCNT1CDK9 | |
| SCHEMBL26129297 | 0.79 | DYRK1A (0.38) | PIM1DYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL26133052 | 0.79 | DYRK1A (0.47) | PIM1HRH3DYRK3CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101640-A1 | FUSED HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF MALARIA | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2011-08-25 | — | — | WO | disclosed |
| WO-2011101640-A1 | FUSED HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF MALARIA | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2011-08-25 | — | — | WO | disclosed |