Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 3/20 | 0.49 |
| ▸ | ARG1 | P05089 | 1/20 | 0.41 |
| ▸ | ARG2 | P78540 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22359167 | 0.88 | SMN1; SMN2 (0.46) | GBA1ARG1ARG2KDM4EMAPT | |
| SCHEMBL1794055 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2BCHEGAA | |
| SCHEMBL3580053 | 0.84 | SMN1; SMN2 (0.53) | GBA1ARG1ARG2KDM4EMAPT | |
| SCHEMBL22359173 | 0.83 | GBA1 (0.46) | GBA1ARG1ARG2CACNA2D1CACNA1B | |
| SCHEMBL22358960 | 0.82 | GBA1 (0.49) | GBA1ARG1ARG2CACNA2D1CACNA1B | |
| SCHEMBL22359134 | 0.80 | BCHE (0.45) | GBA1KDM4ECACNA2D1CACNA1BCACNB1 | |
| SCHEMBL24379284 | 0.75 | GBA1 (0.61) | GBA1ARG1ARG2CACNA2D1CACNA1B | |
| SCHEMBL31306568 | 0.75 | GBA1 (0.61) | GBA1ARG1ARG2CYP2D6CACNA2D1 | |
| SCHEMBL22359132 | 0.75 | OPRK1 (0.38) | GBA1ARG1ARG2KDM4EMAPT | |
| SCHEMBL30584851 | 0.75 | SMN1; SMN2 (0.50) | KDM4EMAPTKMT2AATMCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020167518-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2020-08-20 | — | — | WO | disclosed |