Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | FDPS | P14324 | 2/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8028936 | 1.00 | MAPT (0.46) | MAPTFDPSMMP1MMP2MMP3 | |
| SCHEMBL28736797 | 1.00 | MAPT (0.46) | MAPTFDPSMMP1MMP2MMP3 | |
| Bromide SCHEMBL28820215 | 0.97 | MAPT (0.44) | MAPTFDPSMMP1MMP2MMP3 | |
| Hydrochloric Acid SCHEMBL28020247 | 0.97 | MAPT (0.44) | MAPTFDPSMMP1MMP2MMP3 | |
| SCHEMBL237224 | 0.90 | — | — | |
| Phosphonic Acid SCHEMBL608064 | 0.89 | FDPS (0.39) | MAPTFDPSMMP1MMP2MMP3 | |
| SCHEMBL3392230 | 0.83 | FDPS (0.33) | MAPTFDPSMMP1MMP2MMP3 | |
| SCHEMBL15536892 | 0.83 | FDPS (0.33) | MAPTFDPSMMP1MMP2MMP3 | |
| SCHEMBL654555 | 0.83 | — | — | |
| SCHEMBL1299741 | 0.78 | FDPS (0.42) | MAPTFDPSMMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389183-B1 | PHOSPHATE MANAGEMENT WITH SMALL MOLECULES | OPKO IRELAND GLOBAL HOLDINGS LTD (IE) | 2017-05-31 | — | — | EP | disclosed |
| CN-103923143-B | Method for synthesizing dinucleoside tetraphosphate and P2,P3-(dihalo) methylene dinucleoside tetraphosphate | 江西科技师范大学 | 2017-01-11 | — | — | CN | disclosed |
| US-9198923-B2 | Phosphate management with small molecules | Opko Ireland Global Holdings, Ltd. (KY) | 2015-12-01 | — | — | US | disclosed |
| CN-103923143-A | A method for synthesizing dinucleotide tetraphosphoric acid and P2, P3-(dihalo) methylene dinucleotide tetraphosphoric acid | UNIV JIANGXI NORMAL SCI & TECH | 2014-07-16 | — | — | CN | disclosed |
| US-20120028926-A1 | Phosphate Management with Small Molecules | CYTOCHROMA INC. (CA) | 2012-02-02 | — | — | US | disclosed |
| US-7981874-B2 | Phosphorus derivatives as histone deacetylase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2011-07-19 | — | — | US | disclosed |
| US-20090270351-A1 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2009-10-29 | — | — | US | disclosed |
| EP-2049124-A2 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | Merck & Co., Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| US-7368439-B2 | Dinucleoside poly(borano)phosphate derivatives and uses thereof | BAR - ILAN UNIVERSITY (IL) | 2008-05-06 | — | — | US | disclosed |
| WO-2008010985-A2 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2008-01-24 | — | — | WO | disclosed |
| US-20060287271-A1 | Dinucleoside poly(borano)phosphate derivatives and uses thereof | BAR-ILAN UNIVERSITY (IL) | 2006-12-21 | — | — | US | disclosed |
| CN-1649885-A | Cellular Accumulation of Phosphonate Analogs of HIV Protease Inhibitor Compounds and Such Compounds | GILEAD SCIENCES INC (US) | 2005-08-03 | — | — | CN | disclosed |
| EP-0602068-B1 | PROCESS FOR INCREASING POLYAMIDE MOLECULAR WEIGHT WITH ORGANOPHOSPHONIC ACID OR ESTER CATALYSTS IN THE PRESENCE OF ALUMINA-CONTAINING TiO 2? | DU PONT (US) | 1997-04-23 | — | — | EP | disclosed |
| EP-0602068-A1 | PROCESS FOR INCREASING POLYAMIDE MOLECULAR WEIGHT WITH ORGANOPHOSPHONIC ACID OR ESTER CATALYSTS IN THE PRESENCE OF ALUMINA-CONTAINING TiO 2?. | DU PONT (US) | 1994-06-22 | — | — | EP | disclosed |
| EP-0353969-B1 | Catalytic amidation process | DU PONT (US) | 1994-06-08 | — | — | EP | disclosed |
| WO-1993005086-A2 | PROCESS FOR INCREASING POLYAMIDE MOLECULAR WEIGHT WITH ORGANOPHOSPHONIC ACID OR ESTER CATALYSTS IN THE PRESENCE OF ALUMINA-CONTAINING TiO¿2? | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-03-18 | — | — | WO | disclosed |
| US-5142000-A | Process for increasing polyamide molecular weight with organophosphonic acid or ester catalysts in the presence of alumina-containing titanium dioxide | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-08-25 | — | — | US | disclosed |
| US-4912175-A | Heating | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-03-27 | — | — | US | disclosed |
| WO-1990001513-A1 | CATALYTIC AMIDATION PROCESS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-02-22 | — | — | WO | disclosed |
| EP-0353969-A1 | Catalytic amidation process | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-02-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028926-A1 | Phosphate Management with Small Molecules | SLC34A2, PHPT1, SLC34A3 | MAPT 1907/4885FDPS 289/4885MMP1 899/4885 |
| US-20060287271-A1 | Dinucleoside poly(borano)phosphate derivatives and uses thereof | P2RY2, P2RY1, P2RY11 | MAPT 4878/4885FDPS 535/4885MMP1 2969/4885 |
| US-20090270351-A1 | PHOSPHORUS DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | HDAC5, PPM1A, PTEN | MAPT 1326/4885FDPS 3007/4885MMP1 560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.