Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20837882 | 0.84 | TP53 (0.44) | ALDH1A1SMN1; SMN2MAPTTSHRLMNA | |
| SCHEMBL22359606 | 0.82 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2MAPTTSHRLMNA | |
| SCHEMBL28597800 | 0.82 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2MAPTTSHRLMNA | |
| SCHEMBL20604669 | 0.82 | MEN1 (0.57) | ALDH1A1SMN1; SMN2MAPTTSHRLMNA | |
| SCHEMBL20604616 | 0.81 | LMNA (0.46) | ALDH1A1SMN1; SMN2MAPTTSHRLMNA | |
| SCHEMBL20604620 | 0.81 | LMNA (0.46) | ALDH1A1SMN1; SMN2MAPTTSHRLMNA | |
| SCHEMBL20604679 | 0.80 | LMNA (0.45) | ALDH1A1SMN1; SMN2MAPTTSHRLMNA | |
| SCHEMBL20604642 | 0.79 | HTT (0.49) | ALDH1A1SMN1; SMN2MAPTTSHRLMNA | |
| SCHEMBL20604670 | 0.78 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2MAPTTSHRLMNA | |
| SCHEMBL20604603 | 0.74 | CYP19A1 (0.46) | ALDH1A1SMN1; SMN2MAPTTSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423443-B1 | CYANO-SUBSTITUTED INDOLE COMPOUNDS AND USES THEREOF AS LSD1 INHIBITORS | NOVARTIS AG (CH) | 2020-08-19 | — | — | EP | disclosed |