⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12685102 | 0.73 | — | — | |
| SCHEMBL19077856 | 0.68 | KDM1A (0.35) | — | |
| SCHEMBL28576254 | 0.68 | BRS3 (0.35) | — | |
| SCHEMBL15747143 | 0.67 | TSHR (0.36) | — | |
| SCHEMBL30364270 | 0.66 | GSK3B (0.41) | — | |
| SCHEMBL19087011 | 0.65 | NPY5R (0.41) | — | |
| SCHEMBL15372087 | 0.65 | NPY5R (0.45) | — | |
| SCHEMBL17571952 | 0.65 | NPY5R (0.45) | — | |
| SCHEMBL15586080 | 0.63 | F10 (0.35) | — | |
| SCHEMBL19116608 | 0.61 | BRS3 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3792256-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | Incyte Corporation (US) | 2021-03-17 | — | — | EP | disclosed |
| EP-3400221-B1 | PYRAZOL / IMIDAZOL SUBSTITUTED PYRIDINES AS PI3K-GAMMA INHIBITORS | INCYTE CORP (US) | 2020-08-26 | — | — | EP | disclosed |