Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.50 |
| ▸ | ACACB | O00763 | 4/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 4/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2232561 | 0.85 | MAPT (0.47) | APPACACBALDH1A1KDM4EMAPT | |
| SCHEMBL13582053 | 0.82 | KDM4E (0.44) | ACACBALDH1A1KDM4EMEN1GAA | |
| SCHEMBL13582057 | 0.82 | KDM4E (0.44) | ACACBALDH1A1KDM4EMEN1GAA | |
| SCHEMBL2236524 | 0.78 | APP (0.54) | APPFDPSALDH1A1MEN1LMNA | |
| SCHEMBL2236518 | 0.78 | ALOX5 (0.43) | ACACBKDM4E | |
| SCHEMBL13583137 | 0.76 | APP (0.43) | APPACACBFDPSALDH1A1MEN1 | |
| SCHEMBL13583139 | 0.76 | APP (0.43) | APPACACBFDPSALDH1A1MEN1 | |
| SCHEMBL3147305 | 0.75 | CA12 (0.52) | FDPSALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL3147310 | 0.75 | CA12 (0.52) | FDPSALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL12173624 | 0.75 | APP (0.66) | APPALDH1A1LMNAMAPTMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011093524-A1 | DI - SUBSTITUTED PYRIDINE DERIVATIVES AS ANTICANCERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-08-04 | — | — | WO | disclosed |