SCHEMBL2236561

SCHEMBL2236561

OC[C@H]1OC(O)[C@](O)(F)[C@@H]1O

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CDA P32320 8/20 0.35
PDE4D Q08499 1/20 0.32
PDE3A Q14432 1/20 0.32
SLC29A1 Q99808 1/20 0.32
ALDH1A1 P00352 2/20 0.31
TSHR P16473 2/20 0.31
LMNA P02545 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
PYGB P11216 3/20 0.31
LGALS9 O00182 1/20 0.30
LGALS8 O00214 1/20 0.30
LGALS1 P09382 1/20 0.30
LGALS3 P17931 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18789291 1.00 CDA (0.35) CDAPDE4DPDE3ASLC29A1ALDH1A1
SCHEMBL8857031 1.00 CDA (0.35) CDAPDE4DPDE3ASLC29A1ALDH1A1
SCHEMBL8857040 1.00 CDA (0.35) CDAPDE4DPDE3ASLC29A1ALDH1A1
SCHEMBL17610102 0.87 LGALS1 (0.36) ALDH1A1TSHRLMNATDP1PYGB
SCHEMBL6837637 0.87 LGALS1 (0.36) ALDH1A1TSHRLMNATDP1PYGB
SCHEMBL6837636 0.87 LGALS1 (0.36) ALDH1A1TSHRLMNATDP1PYGB
SCHEMBL27818667 0.87 LGALS1 (0.36) ALDH1A1TSHRLMNATDP1PYGB
SCHEMBL14416499 0.79 CDA (0.42) CDAPDE4DPDE3ASLC29A1ALDH1A1
SCHEMBL3359938 0.79 CDA (0.42) CDAPDE4DPDE3ASLC29A1ALDH1A1
SCHEMBL15603335 0.79 CDA (0.42) CDAPDE4DPDE3ASLC29A1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2976351-B1 LIPOHILLIC OLIGONUCLEOTIDE ANALOGS MILTENYI BIOTEC GMBH (DE) 2018-02-21 EP disclosed
US-9803198-B2 Lipohillic oligonucleotide analogs MILTENYI BIOTEC, GMBH (DE) 2017-10-31 US disclosed
EP-2976351-A1 LIPOHILLIC OLIGONUCLEOTIDE ANALOGS Miltenyi Biotec GmbH (DE) 2016-01-27 EP disclosed
US-20160017325-A1 LIPOHILLIC OLIGONUCLEOTIDE ANALOGS MILTENYI BIOTEC GMBH (DE) 2016-01-21 US disclosed
US-9156875-B2 Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties ADIUTIDE PHARMACEUTICALS GMBH (DE) 2015-10-13 US disclosed
EP-2883957-A1 Immunostimmulatory oligoribonucleotides Zoetis Belgium S.A. (BE) 2015-06-17 EP disclosed
EP-1957647-B1 IMMUNOSTIMULATORY OLIGORIBONUCLEOTIDES ZOETIS BELGIUM S A (BE) 2015-03-04 EP disclosed
EP-2207787-B1 IMMUNE STIMULATORY OLIGORIBONUCLEOTIDE ANALOGS CONTAINING MODIFIED OLIGOPHOSPHATE MOIETIES ADIUTIDE PHARMACEUTICALS GMBH (DE) 2014-11-12 EP disclosed
WO-2014147095-A1 LIPOHILLIC OLIGONUCLEOTIDE ANALOGS MILTENYI BIOTEC GMBH (DE) 2014-09-25 WO disclosed
EP-2781523-A1 Lipophilic oligonucleotide analogs Miltenyi Biotec GmbH (DE) 2014-09-24 EP disclosed
EP-2104738-A2 OLIGORIBONUCLEOTIDES AND USES THEREOF Coley Pharmaceuticals GmbH (DE) 2009-09-30 EP disclosed
WO-2009060281-A2 IMMUNE STIMULATORY OLIGORIBONUCLEOTIDE ANALOGS CONTAINING MODIFIED OLIGOPHOSPHATE MOIETIES COLEY PHARMACEUTICAL GMBH (DE) 2009-05-14 WO disclosed
WO-2008139262-A2 OLIGORIBONUCLEOTIDES AND USES THEREOF COLEY PHARMACEUTICAL GMBH (DE) 2008-11-20 WO disclosed
EP-1957647-A2 IMMUNOSTIMULATORY OLIGORIBONUCLEOTIDES Coley Pharmaceutical GmbH (DE) 2008-08-20 EP disclosed
WO-2008033432-A2 IMMUNE MODULATION BY CHEMICALLY MODIFIED RIBONUCLEOSIDES AND OLIGORIBONUCLEOTIDES COLEY PHARMACEUTICAL GROUP, INC. (US) 2008-03-20 WO disclosed
EP-1899467-A2 MODIFIED OLIGORIBONUCLEOTIDE ANALOGS WITH ENHANCES IMMUNOSTIMULATORY ACTIVITY Coley Pharmaceutical GmbH (DE) 2008-03-19 EP disclosed
US-20070142315-A1 Immunostimulatory oligoribonucleotides COLEY PHARMACEUTICAL GMBH (DE) 2007-06-21 US disclosed
WO-2007062107-A2 IMMUNOSTIMULATORY OLIGORIBONUCLEOTIDES COLEY PHARMACEUTICAL GMBH (DE) 2007-05-31 WO disclosed
WO-2006116458-A2 MODIFIED OLIGORIBONUCLEOTIDE ANALOGS WITH ENHANCES IMMUNOSTIMULATORY ACTIVITY COLEY PHARMACEUTICAL GMBH (DE) 2006-11-02 WO disclosed
US-20060241076-A1 Modified oligoribonucleotide analogs with enhanced immunostimulatory activity COLEY PHARMACEUTICAL GMBH (DE) 2006-10-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070142315-A1 Immunostimulatory oligoribonucleotides TLR9, TLR8, TLR3 CDA 382/4885PDE4D 397/4885PDE3A 1948/4885
US-20060241076-A1 Modified oligoribonucleotide analogs with enhanced immunostimulatory activity TLR3, TLR8, TLR9 CDA 232/4885PDE4D 353/4885PDE3A 2341/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.