Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 3/20 | 0.56 |
| ▸ | CCNC | P24863 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | NPY1R | P25929 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPY2R | P49146 | 1/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6071292 | 0.83 | CCNC (0.52) | CDK8CCNCALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6071296 | 0.83 | CCNC (0.52) | CDK8CCNCALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL22319877 | 0.82 | CYP1A2 (0.55) | CDK8CCNCALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5292811 | 0.82 | HDAC8 (0.64) | ALDH1A1MAPTSMN1; SMN2CYP1A2HPGD | |
| SCHEMBL3936765 | 0.81 | CDK8 (0.55) | CDK8CCNCALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11882678 | 0.76 | HTT (0.54) | ALDH1A1MAPTSMN1; SMN2CYP1A2HPGD | |
| SCHEMBL5593811 | 0.75 | CCNC (0.50) | CDK8CCNCALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7260322 | 0.75 | CCNC (0.52) | CDK8CCNCALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9433705 | 0.74 | CYP1A2 (0.46) | CDK8ALDH1A1MAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL4071696 | 0.74 | CCNC (0.54) | CDK8CCNCALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3700911-B1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2023-09-06 | — | — | EP | disclosed |
| CN-111511750-B | Macrocyclic derivatives, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2023-06-13 | — | — | CN | disclosed |
| EP-3700911-A1 | NOVEL MACROCYCLIC DERIVATIVES, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier SAS (FR) | 2020-09-02 | — | — | EP | disclosed |
| CN-111511750-A | Novel macrocyclic derivatives, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2020-08-07 | — | — | CN | disclosed |