SCHEMBL5292811

SCHEMBL5292811

COC(=O)C=Cc1cccc2ccccc12

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 1/20 0.64
HDAC6 Q9UBN7 1/20 0.64
MTNR1A P48039 1/20 0.58
MTNR1B P49286 1/20 0.58
BACE1 P56817 1/20 0.54
SMN1; SMN2 Q16637 4/20 0.54
MAPT P10636 3/20 0.54
ALDH1A1 P00352 2/20 0.54
CYP1A1 P04798 1/20 0.54
CYP1A2 P05177 1/20 0.54
CYP2D6 P10635 1/20 0.54
HPGD P15428 1/20 0.54
NPY1R P25929 1/20 0.54
MAPK1 P28482 1/20 0.54
NPY2R P49146 1/20 0.54
CYP1B1 Q16678 1/20 0.54
PLK1 P53350 1/20 0.51
NPC1 O15118 2/20 0.50
KDM4E B2RXH2 2/20 0.50
RAB9A P51151 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5593811 0.86 CCNC (0.50) HDAC8HDAC6MTNR1AMTNR1BBACE1
Cyclopropane SCHEMBL11853273 0.85 HDAC8 (0.51) HDAC8HDAC6MTNR1AMTNR1BBACE1
SCHEMBL23606857 0.84 KMT2A (0.49) HDAC8HDAC6MTNR1AMTNR1BSMN1; SMN2
SCHEMBL29162887 0.84 HDAC8 (0.60) HDAC8HDAC6MTNR1AMTNR1BBACE1
SCHEMBL10438847 0.84 ALDH1A1 (0.58) SMN1; SMN2MAPTALDH1A1CYP1A2HPGD
SCHEMBL69522 0.84 ALDH1A1 (0.58) SMN1; SMN2MAPTALDH1A1CYP1A2HPGD
SCHEMBL5459262 0.83 MTNR1A (0.53) HDAC8HDAC6MTNR1AMTNR1BBACE1
SCHEMBL5399861 0.83 HDAC8 (0.55) HDAC8HDAC6MTNR1AMTNR1BBACE1
SCHEMBL14930449 0.83 L3MBTL1 (0.52) HDAC8HDAC6MTNR1AMTNR1BSMN1; SMN2
SCHEMBL2690695 0.83 HDAC8 (0.55) HDAC8HDAC6MTNR1AMTNR1BBACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104311415-B A kind of carboxylic acid and the method for dimethyl malenate esterification 苏州波菲特新材料科技有限公司 2016-08-17 CN disclosed
CN-104311415-A Method for etherification of carboxyl acid and dimethyl malonate SUZHOU BOFEITE NEW MATERIAL TECHNOLOGY CO LTD 2015-01-28 CN disclosed
EP-1313560-B1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION UNIV YALE (US) 2007-12-19 EP disclosed
EP-1313560-A4 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION UNIV YALE (US) 2005-02-09 EP disclosed
EP-1313560-A1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION YALE UNIVERSITY (US) 2003-05-28 EP disclosed
US-6562989-B2 Bicyclopentyl iron ligand and transition metal catalyst YALE UNIVERSITY 2003-05-13 US disclosed
US-20030008768-A1 Catalyst for aromatic C-O, C-N, and C-C bond formation NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-01-09 US disclosed
WO-2002011883-A1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION YALE UNIVERSITY (US) 2002-02-14 WO disclosed
EP-0376516-B1 METHOD OF PREPARATION OF NABUMETONE HOECHST CELANESE CORPORATION (US) 1993-02-10 EP disclosed
EP-0376516-A1 Method of preparation of nabumetone HOECHST CELANESE CORPORATION (US) 1990-07-04 EP disclosed