Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | GAA | P10253 | 2/20 | 0.78 |
| ▸ | LMNA | P02545 | 2/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 9/20 | 0.60 |
| ▸ | RAB9A | P51151 | 9/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | RRM1 | P23921 | 1/20 | 0.55 |
| ▸ | RRM2 | P31350 | 1/20 | 0.55 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17067847 | 0.91 | LMNA (0.74) | ALDH1A1MEN1KMT2AGAALMNA | |
| SCHEMBL19441405 | 0.90 | LMNA (0.73) | ALDH1A1MEN1KMT2AGAALMNA | |
| SCHEMBL1206597 | 0.88 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AGAALMNA | |
| SCHEMBL1206598 | 0.88 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AGAALMNA | |
| SCHEMBL19441406 | 0.86 | LMNA (0.78) | ALDH1A1MEN1KMT2AGAALMNA | |
| SCHEMBL19449620 | 0.84 | ALDH1A1 (0.69) | ALDH1A1MEN1KMT2AGAALMNA | |
| SCHEMBL30423425 | 0.83 | ALDH1A1 (0.76) | ALDH1A1MEN1KMT2AGAALMNA | |
| Hydrochloric Acid SCHEMBL17560906 | 0.83 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2AGAALMNA | |
| SCHEMBL31058805 | 0.83 | ALDH1A1 (0.76) | ALDH1A1MEN1KMT2AGAALMNA | |
| SCHEMBL7747580 | 0.82 | ALDH1A1 (0.74) | ALDH1A1MEN1KMT2AGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200316011-A1 | Targeting Mcl-1 to Enhance DNA Replication Stress Sensitivity for Cancer Therapy | UNIV EMORY (US) | 2020-10-08 | — | — | US | claimed |
| EP-3700524-A1 | INHIBITORS OF MCL-1, COMPOSITIONS, AND USES IN MANAGING CANCER | Emory University (US) | 2020-09-02 | — | — | EP | claimed |
| US-20230060792-A1 | Targeting Mcl-1 to Enhance DNA Replication Stress Sensitivity for Cancer Therapy | UNIV EMORY (US) | 2023-03-02 | — | — | US | disclosed |
| US-11524000-B2 | Targeting Mcl-1 to enhance DNA replication stress sensitivity for cancer therapy | EMORY UNIVERSITY (US) | 2022-12-13 | — | — | US | disclosed |
| US-20200316011-A1 | Targeting Mcl-1 to Enhance DNA Replication Stress Sensitivity for Cancer Therapy | UNIV EMORY (US) | 2020-10-08 | — | — | US | disclosed |
| EP-3700524-A1 | INHIBITORS OF MCL-1, COMPOSITIONS, AND USES IN MANAGING CANCER | Emory University (US) | 2020-09-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230060792-A1 | Targeting Mcl-1 to Enhance DNA Replication Stress Sensitivity for Cancer Therapy | MCL1, PARP1, MRE11 | ALDH1A1 1117/4885MEN1 1749/4885KMT2A 651/4885 |
| US-11524000-B2 | Targeting Mcl-1 to enhance DNA replication stress sensitivity for cancer therapy | MCL1, PARP1, MRE11 | ALDH1A1 1117/4885MEN1 1749/4885KMT2A 651/4885 |
| US-20200316011-A1 | Targeting Mcl-1 to Enhance DNA Replication Stress Sensitivity for Cancer Therapy | MCL1, PARP1, MRE11 | ALDH1A1 1117/4885MEN1 1749/4885KMT2A 651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.