⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318422 | 0.81 | PGR (0.36) | — | |
| SCHEMBL4142319 | 0.78 | PGR (0.39) | — | |
| SCHEMBL1450405 | 0.73 | — | — | |
| SCHEMBL18345450 | 0.70 | — | — | |
| SCHEMBL4065727 | 0.69 | — | — | |
| SCHEMBL4063260 | 0.69 | — | — | |
| SCHEMBL16870529 | 0.69 | GRIN2D (0.45) | — | |
| SCHEMBL12228571 | 0.69 | — | — | |
| SCHEMBL1451016 | 0.68 | PGR (0.33) | — | |
| SCHEMBL5401407 | 0.68 | TDP1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3700906-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | Prelude Therapeutics, Incorporated (US) | 2020-09-02 | — | — | EP | claimed |
| EP-3700906-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | Prelude Therapeutics, Incorporated (US) | 2020-09-02 | — | — | EP | disclosed |