Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17623476 | 1.00 | MAPT (0.42) | MAPTGAAALDH1A1HSD17B10TSHR | |
| SCHEMBL22053899 | 1.00 | MAPT (0.42) | MAPTGAAALDH1A1HSD17B10TSHR | |
| Kynurenine SCHEMBL20702077 | 0.79 | KDM4E (0.57) | MAPTGAAKDM4EHIF1ATDP1 | |
| SCHEMBL20340906 | 0.79 | ALDH1A1 (0.47) | MAPTGAAALDH1A1HSD17B10TSHR | |
| SCHEMBL17483631 | 0.79 | ALDH1A1 (0.47) | MAPTGAAALDH1A1HSD17B10TSHR | |
| Kynurenine SCHEMBL25426098 | 0.78 | KDM4E (0.56) | MAPTGAAKDM4EHIF1ATDP1 | |
| SCHEMBL17623477 | 0.78 | RXFP1 (0.39) | MAPTGAAALDH1A1HSD17B10TSHR | |
| SCHEMBL18637902 | 0.78 | ABL1 (0.46) | MAPTALDH1A1HSD17B10TSHRKDM4E | |
| SCHEMBL247554 | 0.77 | KDM4E (0.47) | MAPTGAAALDH1A1HSD17B10TSHR | |
| Kynurenine SCHEMBL2181581 | 0.77 | KDM4E (0.64) | MAPTGAAALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3078744-B1 | ANTIGEN-BINDING MOLECULES, THE ANTIGEN-BINDING ACTIVITY OF WHICH VARIES ACCORDING TO THE CONCENTRATION OF COMPOUNDS, AND LIBRARIES OF SAID MOLECULES | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2020-08-26 | — | — | EP | disclosed |